©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2016; 22(32): 7275-7288
Published online Aug 28, 2016. doi: 10.3748/wjg.v22.i32.7275
Published online Aug 28, 2016. doi: 10.3748/wjg.v22.i32.7275
Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer
Shih-Hung Yang, Jhe-Cyuan Guo, Chiun Hsu, Chih-Hung Hsu, Kun-Huei Yeh, Ann-Lii Cheng, Sung-Hsin Kuo, Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei 100, Taiwan
Shih-Hung Yang, Ann-Lii Cheng, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei 100, Taiwan
Shih-Hung Yang, Jhe-Cyuan Guo, Graduate Institute of Clinical Medicine National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei 100, Taiwan
Ting-Chun Kuo, Department of Traumatology, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei 100, Taiwan
Hsu Wu, Department of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Yunlin 655, Taiwan
Chiun Hsu, Chih-Hung Hsu, Kun-Huei Yeh, Ann-Lii Cheng, Sung-Hsin Kuo, Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei 100, Taiwan
Yu-Wen Tien, Department of Surgery, National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei 100, Taiwan
Author contributions: Yang SH contributed to drafting the article; Kuo TC, Wu H and Guo JC contributed to acquisition and interpretation of the literature information; Hsu C, Hsu CH, Tien YW, Cheng AL, Yeh KH and Kuo SH contributed to critical revision for important intellectual content and final approval of the version to be published.
Conflict-of-interest statement: The authors declare no conflict of interest.
Correspondence to: Sung-Hsin Kuo, MD, PhD, Department of Oncology, National Taiwan University Hospital and National Taiwan University Cancer Center, No. 7, Chung-Shan South Road, Taipei 100, Taiwan. shkuo101@ntu.edu.tw
Telephone: +886-2-23123456- 67144 Fax: +886-2-23711174
Received: March 29, 2016
Peer-review started: April 5, 2016
First decision: May 12, 2016
Revised: June 20, 2016
Accepted: July 21, 2016
Article in press: July 21, 2016
Published online: August 28, 2016
Processing time: 147 Days and 17.3 Hours
Peer-review started: April 5, 2016
First decision: May 12, 2016
Revised: June 20, 2016
Accepted: July 21, 2016
Article in press: July 21, 2016
Published online: August 28, 2016
Processing time: 147 Days and 17.3 Hours
Core Tip
Core tip: Radiotherapy causes DNA damage, including double-strand breaks, which is more readily repaired in normal cells than in cancerous cells. Radiosensitization, using DNA repair pathway inhibitors, has been well documented in various cancer types, including pancreatic cancer. Further development of optimal protocols, for the combined use of these inhibitors with radiotherapy, with/without chemotherapy, is warranted for the clinical treatment of pancreatic cancer.