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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2015; 21(39): 11127-11140
Published online Oct 21, 2015. doi: 10.3748/wjg.v21.i39.11127
Published online Oct 21, 2015. doi: 10.3748/wjg.v21.i39.11127
Effect of fibulin-5 on adhesion, migration and invasion of hepatocellular carcinoma cells via an integrin-dependent mechanism
Jia-Cheng Tang, Jing-Hua Liu, Xiao-Long Liu, Xiao Liang, Xiu-Jun Cai, Key Lab of Surgery of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Author contributions: Tang JC carried out the experiments and drafted the manuscript; Liu JH and Liu XL participated in the experiments; Liang X analysed the data; Cai XJ designed the study and directed its implementation; all authors drafted the article and made critical revisions related to the intellectual content of the manuscript, and approved the final version of the article to be published.
Supported by Zhejiang Provincial Natural Science Foundation of China, No. LY13H180001; and Education Bureau of Zhejiang Province, No. N20130416.
Institutional review board statement: All samples from the patients were taken after informed consent and ethical permission were obtained for participation in the study.
Conflict-of-interest statement: To the best of our knowledge, all the listed authors have participated actively in the study, and have seen and approved the submitted manuscript. The authors do not have any possible conflicts of interest.
Data sharing statement: We confirm that no additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiu-Jun Cai, MD, PhD, Key Lab of Surgery of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. cxjzu@hotmail.com
Telephone: +86-571-86006605 Fax: +86-571-86006605
Received: May 18, 2015
Peer-review started: May 20, 2015
First decision: June 19, 2015
Revised: July 8, 2015
Accepted: August 30, 2015
Article in press: August 30, 2015
Published online: October 21, 2015
Processing time: 153 Days and 14.3 Hours
Peer-review started: May 20, 2015
First decision: June 19, 2015
Revised: July 8, 2015
Accepted: August 30, 2015
Article in press: August 30, 2015
Published online: October 21, 2015
Processing time: 153 Days and 14.3 Hours
Core Tip
Core tip: Fibulin-5 (FBLN-5) is a matricellular protein that contains an arginine-glycine-aspartic acid motif, the role of which is to bind certain integrins and thereby mediate cancer cell motility. Several studies have revealed that FBLN-5 may promote or suppress tumor progression through its interaction with integrins in various human tumors in a context-specific manner, which might be a crucial event in the invasiveness of malignant tumor cells.