©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2015; 21(36): 10375-10384
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10375
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10375
Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice
Wan-Qin Liao, Ya-Lei Qi, Lin Wang, Xiao-Ming Dong, Tao Xu, Chao-Dong Ding, Rui Liu, Wei-Cheng Liang, Li-Ting Lu, Xin-Cheng Lu, School of Basic Medical Science, Wenzhou Medical University, Chashan Campus, Chashan University Town, Wenzhou 325027, Zhejiang Province, China
He Li, Wen-Feng Li, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China
Guang-Bin Luo, Departments of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, United States
Author contributions: Qi YL, Wang L, Dong XM, Xu T and Ding CD performed the experiments; Liu R and Liang WC analyzed the data; Lu LT, Li H and Li WF provided technical assistances; Luo GB provided assistance in manuscript writing; Liao WQ and Lu XC designed the research and wrote the manuscript; all authors have read and approved the manuscript.
Supported by National Natural Science Foundation of China, No. 81101472 and No. 81472556 (to Liao W), and No. 81372490 (to Lu X); Zhejiang Provincial Natural Science Foundation, No. LZ14H160003 (to Lu X); Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents (to Lu X); National Basic Research Program of China (973 Project), No. 2011CB504603; and Wenzhou Municipal Science and Technology Bureau Foundation, No. Y20110090 (to Li H).
Institutional review board statement: The study was reviewed and approved by the Wenzhou Medical University Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Wenzhou Medical University (approval ID WYDW-20120081).
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
Correspondence to: Xin-Cheng Lu, Professor, School of Basic Medical Science, Wenzhou Medical University, Chashan Campus, Chashan University Town, Wenzhou 325027, Zhejiang Province, China. xinchenglu@yahoo.com
Telephone: +86-577-88831350 Fax: +86-577-88831359
Received: April 9, 2015
Peer-review started: April 9, 2015
First decision: May 18, 2015
Revised: May 26, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: September 28, 2015
Processing time: 171 Days and 21.9 Hours
Peer-review started: April 9, 2015
First decision: May 18, 2015
Revised: May 26, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: September 28, 2015
Processing time: 171 Days and 21.9 Hours
Core Tip
Core tip: Wild type and Recql5-deficient mice were intraperitoneally injected with lipopolysaccharide and D-galactosamine (LPS/D-Gal). The aim of the study was to explore the effects of Recql5 deficiency on LPS/D-Gal-induced liver injury. Our findings reveal that Recql5 protects against liver injury via inhibition of hepatocyte apoptosis and oxidative stress and regulation of hepatic CYP450 expression levels.