Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2015; 21(33): 9817-9821
Published online Sep 7, 2015. doi: 10.3748/wjg.v21.i33.9817
Perforated appendiceal diverticulitis associated with appendiceal neurofibroma in neurofibromatosis type 1
Akihiko Ozaki, Manabu Tsukada, Kazuo Watanabe, Masaharu Tsubokura, Shigeaki Kato, Tetsuya Tanimoto, Masahiro Kami, Hiromichi Ohira, Yukio Kanazawa
Akihiko Ozaki, Manabu Tsukada, Hiromichi Ohira, Division of Surgery, Minamisoma Municipal General Hospital, Fukushima 975-0033, Japan
Kazuo Watanabe, Division of Diagnostic Pathology, Fukushima Pathology Laboratory, Fukushima 960-8164, Japan
Masaharu Tsubokura, Masahiro Kami, Division of Social Communication System for Advanced Clinical Research, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-0071, Japan
Shigeaki Kato, Division of Internal Medicine, Soma Central Hospital, Fukushima 976-0016, Japan
Tetsuya Tanimoto, Jyoban Hospital of Tokiwakai Group, Fukushima 972-8322, Japan
Yukio Kanazawa, Division of Endoscopy, Minamisoma Municipal General Hospital, Fukushima 975-0033, Japan
Author contributions: Ozaki A, Tsukada M and Ohira H performed an operation, managed the patient, and wrote the paper; Watanabe K performed a pathological examination, and contributed to the conception and the design of the study; Tsubokura M, Kato K, Tanimoto T, Kami M and Kanazawa Y contributed to the conception and the design of the study.
Institutional review board statement: The study was reviewed and approved by the Minamisoma Municipal General Hospital Institutional Review Board.
Informed consent statement: The study participant provided informed written consent prior to the study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Akihiko Ozaki, MD, Division of Surgery, Minamisoma Municipal General Hospital, 54-6 Takamicho 2chome, Haramachi, Minamisoma, Fukushima 975-0033, Japan. aozaki-tky@umin.ac.jp
Telephone: +81-244-223181 Fax: +81-244-228853
Received: April 4, 2015
Peer-review started: April 4, 2015
First decision: May 18, 2015
Revised: June 3, 2015
Accepted: July 8, 2015
Article in press: July 8, 2015
Published online: September 7, 2015
Processing time: 156 Days and 10 Hours
Core Tip

Core tip: An appendiceal neurofibroma (ANF) is a rare neoplasm associated with neurofibromatosis type 1 (NF-1), an inheritable neurocutaneous disorder that involves multiple systems including the intraabdominal organs. Appendiceal diverticulitis occasionally ruptures in the absence of intense abdominal pain, which can lead to serious consequences. There is still little information on the association between appendiceal diverticulitis and ANF in NF-1. This patient presented with NF-1 and developed an ANF, complicated with appendiceal diverticulitis, which highlights the possible association of appendiceal diverticulitis and ANF in NF-1. This case could be used to enhance clinicians’ awareness of abdominal manifestations in NF-1.