Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2015; 21(3): 815-819
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.815
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.815
Gastroesophageal reflux disease and non-esophageal cancer
Fernando AM Herbella, Sebastião Pannocchia Neto, Department of Surgery, Federal University of Sao Paulo, Sao Paulo 04037-003, Brazil
Ilka Lopes Santoro, Licia Caldas Figueiredo, Pneumology Division, Department of Medicine, Federal University of Sao Paulo, Sao Paulo 04037-003, Brazil
Author contributions: Both Herbella FAM and Neto SP designed research and wrote the paper; and all authors performed research and analyzed data.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fernando AM Herbella, MD, Department of Surgery, Federal University of Sao Paulo, Rua Diogo de Faria 1087 cj 301, Sao Paulo 04037-003, Brazil. herbella.dcir@epm.br
Telephone: +55-11-99922824 Fax: +55-11-99922824
Received: July 28, 2014
Peer-review started: July 29, 2014
First decision: August 15, 2014
Revised: August 29, 2014
Accepted: October 15, 2014
Article in press: October 15, 2014
Published online: January 21, 2015
Processing time: 175 Days and 21.9 Hours
Peer-review started: July 29, 2014
First decision: August 15, 2014
Revised: August 29, 2014
Accepted: October 15, 2014
Article in press: October 15, 2014
Published online: January 21, 2015
Processing time: 175 Days and 21.9 Hours
Core Tip
Core tip: Gastroesophageal reflux disease (GERD) is a very prevalent disease with a rising incidence. The disease is certainly linked to the pathogenesis of esophageal adenocarcinoma originated in the Barrett’s esophagus. The carcinogenic properties of the gastroduodenal contents may also lead to cancer in target organs for GERD, especially considering that they do not have intrinsic protective mechanisms as found in the esophagus. Although strong conclusions cannot be drawn due to lack of good quality published studies, GERD may also be linked to the pathogenesis of head and neck and lung cancers.