Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2015; 21(27): 8340-8351
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8340
Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice
Fang-Yan Wang, Jia-Ming Liu, Hai-Hua Luo, Ai-Hua Liu, Yong Jiang
Fang-Yan Wang, Hai-Hua Luo, Ai-Hua Liu, Yong Jiang, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Guangzhou 510515, Guangdong Province, China
Fang-Yan Wang, Hai-Hua Luo, Ai-Hua Liu, Yong Jiang, Key Laboratory of Transcriptomics and Proteomics of Ministry of Education of China, Key Laboratory of Proteomics of Guangdong Province, Guangzhou 510515, Guangdong Province, China
Fang-Yan Wang, Hai-Hua Luo, Ai-Hua Liu, Yong Jiang, Department of Pathophysiology, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Fang-Yan Wang, Department of Pathophysiology, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
Jia-Ming Liu, School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
Author contributions: Wang FY and Jiang Y conceived and designed the experiments; Wang FY, Liu JM and Luo HH performed the experiments; Wang FY, Luo HH and Liu AH analyzed the data; Wang FY and Jiang Y wrote the paper.
Supported by grants from The National Key Basic Research (973) Program of China, No. 2010CB529704 (to Jiang Y); the National Natural Science Foundation of China, No.81030055, and No. 81372030 (to Jiang Y); the Guangdong Provincial Natural Science Foundation (S2013010014422) (to Liu A); and the Program of Wenzhou Sci-tech Museum, No. Y20130215 (to Wang FY).
Institutional animal care and use committee statement: All the animal procedures carried out in the present study were in accordance with the guidelines of the Animal Ethics Committee of Wenzhou Medical University.
Conflict-of-interest statement: The authors declare that no competing interests exist.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at jiang48231@163.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yong Jiang, MD, PhD, Department of Pathophysiology, Southern Medical University, No. 1023 Shatai South Road, Guangzhou 510515, Guangdong Province, China. jiang48231@163.com
Telephone: +86-20-61648231 Fax: +86-20-61648231
Received: January 15, 2015
Peer-review started: January 16, 2015
First decision: April 13, 2015
Revised: April 20, 2015
Accepted: May 7, 2015
Article in press: May 7, 2015
Published online: July 21, 2015
Processing time: 188 Days and 4.9 Hours
Core Tip

Core tip: In this study, we reported that the probiotic Clostridium butyricum (C. butyricum) pretreatment obviously attenuated gastric mucosal lesions induced by different stimulations. The oxidative stress- and inflammation-related parameters detected in this study showed that anti-oxidation and anti-inflammation participate in the underlying mechanism of C. butyricum protective effect on gastric mucosa. Our findings provide a potential protective method for the gastric mucosa and a novel application for C. butyricum in the clinic.