Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling

doi:10.3748/wjg.v21.i23.7197

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 21, 2015; 21(23): 7197-7207
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7197

Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling

Yong-Bin Zheng, Gao-Chun Xiao, Shi-Lun Tong, Yu Ding, Qiu-Shuang Wang, Sheng-Bo Li, Zhi-Nan Hao

Yong-Bin Zheng, Gao-Chun Xiao, Shi-Lun Tong, Yu Ding, Qiu-Shuang Wang, Sheng-Bo Li, Zhi-Nan Hao, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China

Author contributions: Zheng YB designed the research; Xiao GC, Tong SL, Ding Y, Wang QS, Li SB and Hao ZN performed the research; Zheng YB and Xiao GC analyzed the data; Zheng YB and Tong SL wrote the paper; all authors had access to the data, attested to the validity of the results, and approved the final article.

Supported by National Natural Science Foundation of China, No. 81372553.

Correspondence to: Yong-Bin Zheng, MD, Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, No. 99 Zhangzhidong Road, Wuchang District, Wuhan 430060, Hubei Province, China. yongbinzhengx@163.com

Telephone: +86-25-2810566 Fax: +86-25-2810568

Received: October 15, 2014
Peer-review started: October 15, 2014
First decision: October 18, 2014
Revised: December 11, 2014
Accepted: February 12, 2015
Article in press: February 13, 2015
Published online: June 21, 2015
Processing time: 247 Days and 21.6 Hours

Core Tip

Core tip: The in vitro data suggest that paeoniflorin is a potential novel therapeutic agent against gastric carcinoma, which inhibits cell viability and induces apoptosis through the up-regulation of microRNA-124 and suppression of phosphatidylinositol 3-kinase/Akt signaling.