Li C, Liu DR, Li GG, Wang HH, Li XW, Zhang W, Wu YL, Chen L. CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway. World J Gastroenterol 2015; 21(20): 6215-6228 [PMID: 26034356 DOI: 10.3748/wjg.v21.i20.6215]
Corresponding Author of This Article
Yu-Lian Wu, PhD, Department of Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310021, Zhejiang Province, China. wuyulian@medmail.com.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
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Li C, Liu DR, Li GG, Wang HH, Li XW, Zhang W, Wu YL, Chen L. CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway. World J Gastroenterol 2015; 21(20): 6215-6228 [PMID: 26034356 DOI: 10.3748/wjg.v21.i20.6215]
Chao Li, Da-Ren Liu, Guo-Gang Li, Hou-Hong Wang, Xiao-Wen Li, Yu-Lian Wu, Li Chen, Department of Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310021, Zhejiang Province, China
Wei Zhang, Department of Orthopedics, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310021, Zhejiang Province, China
Author contributions: Li C and Liu DR contributed equally to this article; Chen L and Wu YL designed the study; Li C, Liu DR, Li GG, Wang HH, Li XW and Zhang W carried out the study; Li C, Liu DR, Li GG, Wu YL and Chen L analyzed the data; Li C and Liu DR wrote the paper; all the authors contributed to the preparation of the manuscript.
Supported by National Natural Science Foundation of China, No. 81101837; Research Fund for the Doctoral Program of Higher Education of China, No. 20110101120129; and Zhejiang Medical Health Science and Technology Plan, No. 2013KYB124.
Ethics approval: The authors have declared that no human samples, human or animal subjects were involved in this study.
Institutional animal care and use committee: The authors have declared that no animals were used in this study.
Conflict-of-interest: The authors have declared that no competing interests exist.
Data sharing: The technical appendix, statistical code, and dataset are available from the corresponding author at wuyulian@medmail.com.cn or chenli_hz@yahoo.com.
Correspondence to: Yu-Lian Wu, PhD, Department of Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310021, Zhejiang Province, China. wuyulian@medmail.com.cn
Telephone: +86-571-87783582 Fax: +86-571-87022776
Received: November 27, 2014 Peer-review started: November 28, 2014 First decision: December 26, 2014 Revised: January 14, 2015 Accepted: February 12, 2015 Article in press: February 13, 2015 Published online: May 28, 2015 Processing time: 184 Days and 1.6 Hours
Core Tip
Core tip: CD97, belongs to the epidermal growth factor-seven-transmembrane subfamily, and has been found to promote proliferation and invasion of gastric cancer cells. However, the underlying mechanism is poorly understood. In this study, we found that exosomes isolated from gastric cancer cells with high CD97 expression promoted tumor cell proliferation and invasion. Furthermore, through microarray and western blot analyses, MAPK signaling pathway activation was observed when cells were treated with those exosomes. These results indicated that CD97 promotes gastric cancer cell proliferation and invasion in vitro, at least in part, through the exosome-mediated MAPK signaling pathway, and exosomal miRNAs are probably involved in activation of the CD97-associated pathway.
