Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2015; 21(12): 3537-3546
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3537
Therapeutic effect of Qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury
Jing-Wen Zhang, Gui-Xin Zhang, Hai-Long Chen, Ge-Liang Liu, Lawrence Owusu, Yu-Xi Wang, Guan-Yu Wang, Cai-Ming Xu
Jing-Wen Zhang, Gui-Xin Zhang, Hai-Long Chen, Lawrence Owusu, Guan-Yu Wang, Cai-Ming Xu, Department of Surgery, The First Affiliated Hospital, Dalian Medical University, Dalian 116011, Liaoning Province, China
Ge-Liang Liu, Yu-Xi Wang, Department of Surgery, The Second Affiliated Hospital, Dalian Medical University, Dalian 116023, Liaoning Province, China
Author contributions: Zhang JW, Zhang GX, and Chen HL designed the research; Zhang JW and Liu GL performed the experiments; Wang YX, Wang GY, Owusu L, and Xu CM analyzed the data; Zhang JW and Owusu L drafted the paper; all authors read, contributed to and approved the final version to be published; Zhang JW and Zhang GX contributed equally to the work and should be regarded as co-first authors.
Supported by National Natural Science Foundation of China, No. 81173452.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hai-Long Chen, PhD, Professor of Medicine, Department of Surgery, The First Affiliated Hospital, Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. hailongchen2007@163.com
Telephone: +86-411-83600680 Fax: +86-411-83631284
Received: August 31, 2014
Peer-review started: September 1, 2014
First decision: October 14, 2014
Revised: November 6, 2014
Accepted: December 20, 2014
Article in press: December 22, 2014
Published online: March 28, 2015
Processing time: 210 Days and 18 Hours
Core Tip

Core tip: Secreted phospholipase A2 (sPLA2) is a damage factor that stimulates excessive inflammatory responses, which can lead to the degradation and hydrolysis of biologic membranes, thus promoting epithelial injury. We demonstrate that sPLA2 is overexpressed at the mRNA and protein levels in a rat model of severe acute pancreatitis-induced intestinal barrier injury. However, a traditional Chinese medicine, Qingyi decoction, effectively antagonized this overexpression of sPLA2 to alleviate the severity of the disease. This observation was comparable to the inhibitory effect of verapamil on sPLA2 expression.