©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Apr 28, 2014; 20(16): 4737-4744
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4737
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4737
Association between NOD2/CARD15 gene polymorphisms and Crohn's disease in Chinese Zhuang patients
Wei-Yan Long, Lan Chen, Cui-Liang Zhang, Rong-Mao Nong, Mei-Jiao Lin, Xiao-Ping Lv, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Ling-Ling Zhan, Department of Clinical Experimental Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Long WY performed the experiments and wrote the manuscript; Zhang CL, Nong RM and Lin MJ collected samples; Chen L and Zhan LL analyzed the data and revised the manuscript; Lv XP designed the research and revised the paper.
Supported by Guangxi Graduate Education Innovation Project Fund, No.YCSZ2012035; the Natural Science Foundation of Guangxi Zhuang Autonomous Region, No. 0832009, No. 2012GXNSFAA053143; and Traditional Chinese Medicine Science Fund of Guangxi Zhuang Autonomous Region, China, No. GZPT1238
Correspondence to: Xiao-Ping Lv, Professor, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. lxxp58@hotmail.com
Telephone: +86-771-3277211 Fax: +86-771-3277285
Received: November 2, 2013
Revised: January 6, 2014
Accepted: January 20, 2014
Published online: April 28, 2014
Processing time: 179 Days and 11.6 Hours
Revised: January 6, 2014
Accepted: January 20, 2014
Published online: April 28, 2014
Processing time: 179 Days and 11.6 Hours
Core Tip
Core tip: In this study, P268S, JW1 and N852S polymorphisms of the NOD2/CARD15 gene were genotyped using the PCR-RFLP method and gene sequencing, and the presence of P268S in Guangxi Zhuang Crohn’s disease patients was identified. However, no JW1 or N852S mutants were found in this cohort.