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World J Gastroenterol. Apr 7, 2014; 20(13): 3693-3697
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3693
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3693
Colonic and anal metastases from pancreato-biliary malignancies
Farshid Ejtehadi, Nikolaos A Chatzizacharias, Emmanuel Huguet, Raaj K Praseedom, Asif Jah, Department of HPB and Transplant Surgery, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridgeshire CB2 0QQ, United Kingdom
Rebecca J Brais, Department of Histopathology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridgeshire CB2 0QQ, United Kingdom
Nigel R Hall, Cambridge Colorectal Unit, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridgeshire, CB2 0QQ, United Kingdom
Edmund M Godfrey, Department of Radiology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridgeshire CB2 0QQ, United Kingdom
Author contributions: All authors contributed in the writing of the manuscript; Brais RJ also conducted the immunohistochemical analysis.
Correspondence to: Dr. Asif Jah, Consultant surgeon, Department of HPB and Transplant Surgery, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridgeshire CB2 0QQ, United Kingdom. asif.jah@addenbrookes.nhs.uk
Telephone: +44-1223-257074 Fax: +44-1223-216015
Received: October 28, 2013
Revised: December 27, 2013
Accepted: January 20, 2014
Published online: April 7, 2014
Processing time: 158 Days and 12.6 Hours
Revised: December 27, 2013
Accepted: January 20, 2014
Published online: April 7, 2014
Processing time: 158 Days and 12.6 Hours
Core Tip
Core tip: Pancreato-biliary malignancies often present with locally advanced or metastatic disease. Surgery is the mainstay of treatment although less than 20% are suitable for resection at presentation. Common sites for metastases are liver, lungs, lymph nodes and peritoneal cavity and carry poor prognosis, with median survival of less than 3 mo. Distal colonic and anorectal metastases from pancreato-biliary cancers are rare and can masquerade as primary colorectal tumours. The key to the diagnosis is the specific immunohistochemical profile of the intestinal lesion biopsies.