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World J Gastroenterol. Aug 28, 2013; 19(32): 5347-5356
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5347
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5347
Efficacy profiles for different concentrations of Lactobacillus acidophilus in experimental colitis
Lin-Lin Chen, Yi-You Zou, Fu-Jun Li, Guang-Hui Lian, Department of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Fang-Gen Lu, Department of Gastroenterology, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China
Author contributions: Chen LL performed the experiments; Zou YY and Lu FG designed the study and revised the article for intellectual content; Li FJ and Lian GH analyzed the data, performed statistical analyses and revised the article for intellectual content.
Correspondence to: Lin-Lin Chen, MD, Department of Gastroenterology, Xiangya Hospital of Central South University, Kaifu District, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China. chenlinlinmedical@gmail.com
Telephone: +86-731-84327332 Fax: +86-731-84327332
Received: March 13, 2013
Revised: June 3, 2013
Accepted: July 18, 2013
Published online: August 28, 2013
Processing time: 168 Days and 5.7 Hours
Revised: June 3, 2013
Accepted: July 18, 2013
Published online: August 28, 2013
Processing time: 168 Days and 5.7 Hours
Core Tip
Core tip: Efficacies of the current treatments for ulcerative colitis (UC) are limited by procedure-related complications, poor patient compliance, and high relapse rates. Administration of supplemental probiotics represents a promising new therapy of UC. Since UC pathogenic sites mainly involve the rectum and colon and UC patients show differential composition profiles of intestinal bacteria, this study was designed to evaluate the therapeutic efficacies of various concentrations for the standard probiotic, Lactobacillus acidophilus, using a well-known murine model of experimental colitis to examine the changes in colitis symptoms and the corresponding effects on the bacterial flora in the distal and proximal colon.