Chojnacki C, Wiśniewska-Jarosińska M, Kulig G, Majsterek I, Reiter RJ, Chojnacki J. Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis. World J Gastroenterol 2013; 19(23): 3602-3607 [PMID: 23801861 DOI: 10.3748/wjg.v19.i23.3602]
Corresponding Author of This Article
Jan Chojnacki, MD, PhD, Department of Gastroenterology, Medical University of Lodzpl, Hallera 1, 90-647 Lodz, Poland. gastrologia@umed.lodz.pl
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 21, 2013; 19(23): 3602-3607 Published online Jun 21, 2013. doi: 10.3748/wjg.v19.i23.3602
Evaluation of enterochromaffin cells and melatonin secretion exponents in ulcerative colitis
Cezary Chojnacki, Maria Wiśniewska-Jarosińska, Grażyna Kulig, Ireneusz Majsterek, Russel J Reiter, Jan Chojnacki
Cezary Chojnacki, Maria Wiśniewska-Jarosińska, Grażyna Kulig, Jan Chojnacki, Department of Gastroenterology, Medical University of Lodz, 90-647 Lodz, Poland
Ireneusz Majsterek, Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 90-647 Lodz, Poland
Russel J Reiter, Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, United States
Author contributions: Chojnacki C conceived the study, and carried out the clinical procedures; Wiśniewska-Jarosińska M participated in study design; Kulig G performed the histopatological procedures and the statistical analysis; Majsterek I performed the biochemical study; Chojnacki J and Reiter RJ participated in the study design and wrote the final version of the paper.
Supported by The Ministry of Science and High Education of Poland, No. NN402 4221/38
Correspondence to: Jan Chojnacki, MD, PhD, Department of Gastroenterology, Medical University of Lodzpl, Hallera 1, 90-647 Lodz, Poland. gastrologia@umed.lodz.pl
Telephone: +48-42-6393049 Fax: +48-42-6393049
Received: October 29, 2012 Revised: April 1, 2013 Accepted: April 18, 2013 Published online: June 21, 2013 Processing time: 234 Days and 0.1 Hours
Core Tip
Core tip: In the gastrointestinal tract melatonin is secreted mainly by enterochromaffin cells (EC). It appears that hydroxyindole-O-methyltransferase (HIOMT) is enzyme determining melatonin synthesis. This indoleamine exert, antioxidant, and anti-inflammatory effects. Its synthesis can be disturbed by pro-inflammatory cytokines. The obtained results noted the proliferation of EC cells and the increase of HIOMT expression in ulcerative colitis ulcerative colitis (UC). Positive correlation between the amount of EC cells and urinary 6-sulfatoxymelatonin excretion points to the increase of melatonin secretion in the colon, but its beneficial anti-inflammatory effect was insufficient. The results indicate that the supplementation of melatonin may be useful in complex treatment of UC.
