Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients

doi:10.3748/wjg.v24.i29.3293

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Aug 7, 2018; 24(29): 3293-3301
Published online Aug 7, 2018. doi: 10.3748/wjg.v24.i29.3293

Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients

Svein Oskar Frigstad, Marte Lie Høivik, Jørgen Jahnsen, Milada Cvancarova, Tore Grimstad, Ingrid Prytz Berset, Gert Huppertz-Hauss, Øistein Hovde, Tomm Bernklev, Bjørn Moum, Lars-Petter Jelsness-Jørgensen

Svein Oskar Frigstad, Department of Medicine, Vestre Viken Bærum Hospital, Gjettum 1346, Norway

Svein Oskar Frigstad, Department of Research, Østfold Hospital Kalnes, Grålum 1714, Norway

Marte Lie Høivik, Bjørn Moum, Department of Gastroenterology, Oslo University Hospital, Oslo 0424, Norway

Jørgen Jahnsen, Department of Gastroenterology, Akershus University Hospital, Lørenskog 1478, Norway

Milada Cvancarova, Faculty of Health Sciences, Oslo Metropolitan University, Oslo 0130, Norway

Tore Grimstad, Department of Gastroenterology, Stavanger University Hospital, Stavanger 4068, Norway

Ingrid Prytz Berset, Department of Medicine, Ålesund Hospital Trust, Ålesund 6026, Norway

Gert Huppertz-Hauss, Department of Gastroenterology, Telemark Hospital Trust, Skien 3710, Norway

Øistein Hovde, Department of Medicine, Innlandet Hospital Trust, Gjøvik 2819, Norway

Tomm Bernklev, Department of Research and Development, Vestfold Hospital Trust, Tønsberg 3103, Norway

Lars-Petter Jelsness-Jørgensen, Department of Gastroenterology, Østfold Hospital Kalnes, Grålum 1714, Norway

Lars-Petter Jelsness-Jørgensen, Department of Health Sciences, Østfold University College, Halden 1757, Norway

Author contributions: Frigstad SO performed the study, analysed the data and wrote the paper; Høivik ML and Cvancarova M analyzed the data, contributed to the design of tables and writing of the paper; Jahnsen J performed the study, contributed to tables and writing of the paper; Grimstad T, Berset IP, Huppertz-Hauss G and Hovde Ø performed the study and contributed to writing of the paper; Bernklev T contributed to the design of the study and writing of the paper; Moum B contributed to the design of the study, performed the study and supervised the writing of the paper; Jelsness-Jørgensen LP designed, supervised and performed the study, contributed to analysing the data and revised the paper; all authors have approved the final manuscript.

Institutional review board statement: The Regional Committee for Medical and Health Research Ethics approved the study. The approval has been uploaded with the submission of the manuscript (2012/845/REK).

Informed consent statement: All the study participants gave written, informed consent before inclusion in the study, and the study was performed in accordance with the Declaration of Helsinki. The consent form that was used has been uploaded with the submission of the manuscript.

Conflict-of-interest statement: The authors declare no conflicts of interest.

Data sharing statement: No additional data are available.

STROBE statement: The guidelines of the STROBE statement have been adopted and a fulfilled version of the checklist has been attached with the submission of the manuscript.

Correspondence to: Svein Oskar Frigstad, MD, Doctor, Research Fellow, Department of Research, Østfold Hospital Kalnes, Postboks 300, Grålum 1714, Norway. s.o.frigstad@medisin.uio.no

Telephone: +47-91508600 Fax: +47-69863285

Received: April 4, 2018
Peer-review started: April 4, 2018
First decision: May 30, 2018
Revised: June 17, 2018
Accepted: June 27, 2018
Article in press: June 27, 2018
Published online: August 7, 2018
Processing time: 121 Days and 20.7 Hours

ARTICLE HIGHLIGHTS

Research background

Fatigue is common in inflammatory bowel diseases (IBD) and is especially prevalent in active disease. Also sleep disturbance, anemia, pain and depression all seem to influence fatigue. However, a relationship between vitamin D and fatigue has not been established.

Research motivation

We wanted to investigate if vitamin D deficiency was associated to fatigue in IBD as this is a common belief among both patients and physicians. To the best of our knowledge, no previous studies have investigated this possible association in IBD patients.

Research objectives

A relationship between vitamin D and fatigue has not been established. We wanted to explore this association and discover possible implications for our patients and further research.

Research methods

The research question was explored in a fairly large cohort of IBD patients from specialist care. The study was designed as an observational study, and all data were collected at inclusion. Linear and logistic regression models were applied to explore the possible association between vitamin D deficiency and total fatigue scores and chronic fatigue, respectively. All vitamin D analyses were done at the same laboratory.

Research results

In this study fatigue was commonly reported. Vitamin D levels were, however, neither associated with total fatigue nor with chronic fatigue. Higher total fatigue scores and chronic fatigue were both associated with increased disease activity scores, but not with objective markers of inflammation. Sleep disturbance and depressive symptoms were associated with total fatigue scores in both ulcerative colitis and Crohn’s disease (CD) patients, but with chronic fatigue only in CD patients.

Research conclusions

In this study, fatigue was associated with clinical disease activity, depression and sleep disturbance. Our data did not reveal any association between vitamin D deficiency and fatigue, supporting a multidimensional approach in the understanding of fatigue.

Research perspectives

The possible associations we report need to be explored in further clinical studies. A randomized controlled trial with an interventional group receiving vitamin D supplementation may shed light on the possible benefits of vitamin D in patient reported outcomes in IBD.