Combined Traditional and Modern Medicine
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 15, 1998; 4(2): 169-170
Published online Apr 15, 1998. doi: 10.3748/wjg.v4.i2.169
Short-term effect of Salvia miltiorrhiza in treating rat acetic acid chronic gastric ulcer and long-term effect in preventing recurrence
Guo-Zhong Wang, Xin Ru, Li-Hua Ding, He-Qun Li
Guo-Zhong Wang, Department of Pathophysiology, the First Affiliated Hospital, Qiqihaer Medical College, Qiqihaer 161042, Hei-longjiang Province, China
Xin Ru, Li-Hua Ding, Surgical Department, the First Affiliated Hospital, Qiqihaer Medical College, Qiqihaer 161042, Hei-longjiang Province, China
He-Qun Li, Department of Pathophysiology, China Medical University, Shenyang 110001, Liaoning Province, China
Guo-Zhong Wang, male, born on 1958-02-16 in Qiqihaer City, Hei-longjiang Province, Han nationality, graduated from China Medical University as a postgraduate in 1993, lecturer of pathophysiology, majoring gastric ulcer pathophysiology, having 12 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Guo-Zhong Wang, Department of Pathophysiology, the First Affiliated Hospital, Qiqihaer Medical College, Qiqihaer161042, Heilongjiang Province, China
Telephone: +86·452·6713981 ext 2066
Received: September 25, 1997
Revised: December 18, 1997
Accepted: January 20, 1998
Published online: April 15, 1998
Abstract

AIM: To study the short-term effect of Danshen (Salvia miltiorrhiza) on acetic acid induced chronic gastric ulcer in rats and its long-term effect in preventing recurrence.

METHODS: Rats with acetic acid-induced gastric ulcer were treated with Danshen and cimetidine for 30 d. Traditional gastric mucosal auto-radiography and 3H-TdR incorporation into gastric mucosa in vitro were employed to study the effects of Danshen in rat acetic acid-induced chronic gastric ulcer, including ulcer index (UI), ulcer inhibitory rate (IR) and label rate (LR).

RESULTS: On the day 5, 30 and 126 of ulcermaking, the UI in the Danshen group was obviously lower than that in the cimetidine group and the control group (42.3 ± 3.9, 3.6 ± 1.2, 4.4 ± 2.3; 49.1 ± 3.6, 5.9 ± 1.4, 9.2 ± 1.3; 61.0 ± 3.8, 8.9 ± 2.5, 12.4 ± 2.4, respectively, P < 0.01), the IR (%) in the Danshen group was obviously higher than that in the cimetidine group (31, 59, 64.8; 19, 33, 26, respectively), and the LR in the Danshen group was obviously higher than that in the cimetidine group and the control group (10.0 ± 0.5, 16.2 ± 0.8, 15.0 ± 0.6; 9.0 ± 0.5, 13.9 ± 0.6, 10.8 ± 0.7; 6.5 ± 0.7, 10.1 ± 0.5, 8.0 ± 0.7, respectively, P < 0.01). There was no obvious difference in UI in the Danshen group on day 30 ascompared with that on day 126.

CONCLUSION: Danshen is effective in promoting ulcer healing and preventing recurrence. The mechanism of action is to strengthen the gastric mucosal barrier and to promote the gastric mucosal cell proliferation along the edge of the ulcer.

Keywords: Danshen; disease models, animal; Salvia miltiorrhiza; stomach ulcer; acetic acid; cimitidine; gastric mucosa; recurrence; rats, Wistar; chronic diseases