Wang YP, Dai JL, Li L, Wen B. Insights into the influencing factors of fecal gut microbiota in hepatocellular carcinoma. World J Gastroenterol 2026; 32(6): 115217 [DOI: 10.3748/wjg.v32.i6.115217]
Corresponding Author of This Article
Biao Wen, MD, Associate Chief Physician, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, No. 278 Middle Section of Baoguang Avenue, Xindu District, Chengdu 610000, Sichuan Province, China. 820695761@qq.com
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Gastroenterology & Hepatology
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Letter to the Editor
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feb 14, 2026 (publication date) through Feb 5, 2026
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World Journal of Gastroenterology
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1007-9327
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Wang YP, Dai JL, Li L, Wen B. Insights into the influencing factors of fecal gut microbiota in hepatocellular carcinoma. World J Gastroenterol 2026; 32(6): 115217 [DOI: 10.3748/wjg.v32.i6.115217]
World J Gastroenterol. Feb 14, 2026; 32(6): 115217 Published online Feb 14, 2026. doi: 10.3748/wjg.v32.i6.115217
Insights into the influencing factors of fecal gut microbiota in hepatocellular carcinoma
Yin-Ping Wang, Jia-Le Dai, Lan Li, Biao Wen
Yin-Ping Wang, Jia-Le Dai, Lan Li, Biao Wen, Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, Sichuan Province, China
Author contributions: Wang YP drafted the initial manuscript; Wen B contributed to the conception, writing, review, and editing of the work; Wang YP, Dai JL, Li L, and Wen B participated in drafting the article. All authors have read and approved the final version of the manuscript.
Supported by Chengdu City Medical Research Project, No. 2022247; and the High-Level Scientific Research Startup Fund Project of the First Affiliated Hospital of Chengdu Medical College, No. CYFY-GQ40.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Biao Wen, MD, Associate Chief Physician, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, No. 278 Middle Section of Baoguang Avenue, Xindu District, Chengdu 610000, Sichuan Province, China. 820695761@qq.com
Received: October 14, 2025 Revised: November 20, 2025 Accepted: December 17, 2025 Published online: February 14, 2026 Processing time: 114 Days and 2 Hours
Abstract
Recently, Feng et al published a significant study. Through multi-omics analysis, their research team revealed associations between fecal metabolome, gut bacteria, and serum indicators in patients with hepatocellular carcinoma (HCC). These results suggest that the composition of the metabolome and gut bacteria in fecal samples hold promise as potential biomarkers for the diagnosis of HCC. After carefully reviewing their work, we offer two points of insight: (1) The influence of different factors on gut microbiota changes in HCC; and (2) The impact of the hepatitis B virus and antiviral drugs on the gut microbiota of patients with HCC.
Core Tip: We critically evaluated the study by Feng et al and offered expert suggestions concerning factors influencing changes in the hepatocellular carcinoma gut microbiota and the impact of the hepatitis B virus and related antiviral drugs on the microbiota, with the aim of advancing this scientific field.
