Copyright
©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Chrono-optimal treatments for human immunodeficiency virus/hepatitis C virus co-infection yield comparable survival outcomes with hepatitis C virus mono-infection
Jeayeon Park, Jae Yoon Jeong, Soon Sun Kim, Jae Hyun Yoon, Hyuk Soo Eun, Jonggi Choi, Ki Tae Yoon, Young Kul Jung, Soo Young Park, Geum-Youn Gwak, Do Young Kim, Ji Hoon Kim, Jin-Woo Lee, Tae Yeob Kim, Jeong Won Jang, Su Jong Yu
Jeayeon Park, Su Jong Yu, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea
Jae Yoon Jeong, Department of Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul 07985, South Korea
Soon Sun Kim, Department of Gastroenterology, Ajou University School of Medicine, Suwon 16499, Gyeonggi-do, South Korea
Jae Hyun Yoon, Department of Gastroenterology and Hepatology, Chonnam National University Hospital and Medical School, Gwangju 61469, South Korea
Hyuk Soo Eun, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, South Korea
Jonggi Choi, Department of Internal Medicine, Asan Medical Center, Seoul 05505, South Korea
Ki Tae Yoon, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, South Korea
Young Kul Jung, Ji Hoon Kim, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, South Korea
Soo Young Park, Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu 41944, South Korea
Geum-Youn Gwak, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea
Do Young Kim, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, South Korea
Jin-Woo Lee, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon 22212, South Korea
Tae Yeob Kim, Department of Internal Medicine, New Hope Internal Medicine Clinic, Seoul 03113, South Korea
Jeong Won Jang, Department of Internal Medicine, The Catholic University of Korea, Seoul 06591, South Korea
Co-first authors: Jeayeon Park and Jae Yoon Jeong.
Co-corresponding authors: Jeong Won Jang and Su Jong Yu.
Author contributions: Park J and Jeong JY contribute equally to this study as co-first authors; Yu SJ and Jang JW contribute equally to this study as co-corresponding authors and they have full access to all study data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis; study concepts and design were performed by Park J, Jeong JY, Kim SS, Yu SJ, and Jang JW; provision of study materials or patients were performed by Park J, Jeong JY, Kim SS, Yoon JH, Eun HS, Choi J, Yoon KT, Jung YK, Park SY, Gwak GY, Kim DY, Kim JH, Lee JW, Kim TY, Yu SJ, and Jang JW; collection and management of the study data were performed by Park J, Jeong JY, Kim SS, Yu SJ, and Jang JW; data analysis and interpretation were performed by Park J, Jeong JY, and Kim SS; manuscript writing was performed by Park J, Jeong JY, Kim SS, Yu SJ, and Jang JW.
Supported by the Research Supporting Program of the Korean Association for the Study of the Liver and the Korean Liver Foundation, No. KASL2021-02.
Institutional review board statement: This study involves human participants and was approved by the Institutional Review Board of Seoul National University Hospital (Approval No. H-2103-086-1205), which served as the central institutional review board for all participating institutions.
Informed consent statement: The requirement to obtain informed consent from patients was waived by the institutional review board due to the retrospective nature of this study.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: All data generated or analyzed during this study are included in this article and its supplementary material files. Further enquiries can be directed to the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Su Jong Yu, MD, PhD, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101, Daehak-Ro Jongno-Gu, Seoul 03080, South Korea.
ydoctor2@snu.ac.kr
Received: September 17, 2025
Revised: November 24, 2025
Accepted: December 15, 2025
Published online: January 21, 2026
Processing time: 122 Days and 9.3 Hours
