Li SH, Niu WW, Huo XX, Zhang H, Shi LM, Liu YT, Xing JJ, Feng ZX, Wang N. Value of endoscopic submucosal dissection in diagnosing gastric mucosa-associated lymphoid tissue lymphoma: A case report. World J Gastroenterol 2025; 31(38): 111549 [DOI: 10.3748/wjg.v31.i38.111549]
Corresponding Author of This Article
Na Wang, Professor, Department of Gastroenterology, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. na_wang@hebmu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 14, 2025; 31(38): 111549 Published online Oct 14, 2025. doi: 10.3748/wjg.v31.i38.111549
Value of endoscopic submucosal dissection in diagnosing gastric mucosa-associated lymphoid tissue lymphoma: A case report
Shuo-Hui Li, Wei-Wei Niu, Xiao-Xia Huo, Hong Zhang, Li-Min Shi, Ya-Ting Liu, Jia-Jing Xing, Zhi-Xin Feng, Na Wang
Shuo-Hui Li, Wei-Wei Niu, Xiao-Xia Huo, Hong Zhang, Li-Min Shi, Ya-Ting Liu, Jia-Jing Xing, Zhi-Xin Feng, Na Wang, Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Author contributions: Li SH researched the data and wrote the manuscript; Niu WW, Huo XX, Zhang H, Shi LM, Liu YT, Xing JJ and Feng ZX contributed to the discussion; Wang N guided the writing ideas and reviewed the manuscript; All authors contributed to the article and approved the final manuscript.
Supported by the Hebei Natural Science Foundation, No. H2023206912.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Na Wang, Professor, Department of Gastroenterology, The Second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. na_wang@hebmu.edu.cn
Received: July 3, 2025 Revised: August 3, 2025 Accepted: September 2, 2025 Published online: October 14, 2025 Processing time: 103 Days and 22.8 Hours
Abstract
BACKGROUND
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma presents with various clinical presentations and endoscopic features. While gastric lesions are primarily assessed via endoscopic forceps biopsy, pathological confirmation of MALT lymphoma is frequently challenging, with low detection rates commonly observed.
CASE SUMMARY
We describe a 61-year-old male patient with gastric MALT lymphoma due to intermittent abdominal discomfort lasting over six months. The initial endoscopic forceps biopsy was suggestive of gastric lymphoma. Confirmation of the MALT lymphoma diagnosis was ultimately obtained through a jumbo biopsy specimen harvested via endoscopic submucosal dissection (ESD).
CONCLUSION
We report a case of gastric MALT lymphoma diagnosed through ESD, highlighting its potential as a diagnostic tool when forceps biopsy yields negative or inconclusive results.
Core Tip: Gastric mucosa-associated lymphoid tissue (MALT) lymphoma has various clinical presentations and endoscopic features. While gastric lesions are primarily assessed via endoscopic forceps biopsy, pathological confirmation of MALT lymphoma is frequently challenging, with low detection rates commonly observed. We report a case of gastric MALT lymphoma diagnosed through endoscopic submucosal dissection, highlighting its potential as a diagnostic tool when forceps biopsy yields negative or inconclusive results.
