Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2025; 31(3): 96582
Published online Jan 21, 2025. doi: 10.3748/wjg.v31.i3.96582
Traditional Chinese medicine in the treatment of Helicobacter pylori-related gastritis: The mechanisms of signalling pathway regulations
Pei-Pei Zhang, Liang Li, Hao-Yu Qu, Guang-Yu Chen, Meng-Zhou Xie, Yan-Kun Chen
Pei-Pei Zhang, Liang Li, Guang-Yu Chen, Meng-Zhou Xie, Yan-Kun Chen, School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410200, Hunan Province, China
Pei-Pei Zhang, Liang Li, Hao-Yu Qu, Guang-Yu Chen, Meng-Zhou Xie, Hunan Engineering Technology Research Center for Medicinal and Functional Food, Hunan University of Chinese Medicine, Changsha 410200, Hunan Province, China
Pei-Pei Zhang, Liang Li, Guang-Yu Chen, Meng-Zhou Xie, Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine, Changsha 410200, Hunan Province, China
Hao-Yu Qu, School of Informatics, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China
Yan-Kun Chen, Precision Medicine Research and Development Center, Zhuhai Institute of Advanced Technology, Chinese Academy of Sciences, Zhuhai 519000, Guangdong Province, China
Co-corresponding authors: Hao-Yu Qu and Meng-Zhou Xie.
Author contributions: Zhang PP and Li L designed the research and study conceptualization; Zhang PP and Xie MZ wrote the paper; Qu HY and Chen GY reviewed the data; Zhang PP and Chen YK revised the manuscript. Qu HY and Xie MZ provided professional advice and contributed equally to this work as co-corresponding authors. All the authors approved the final version of the submitted paper.
Supported by National Natural Science Foundation of China, No. 82374323; and Hunan Graduate Research Innovation Project, No. 2023CX15.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Meng-Zhou Xie, MD, PhD, Professor, School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, No. 300 Bachelor Road, Hanpu Science and Education Park, Yuelu District, Changsha 410200, Hunan Province, China. xiemengzhou@hnucm.edu.cn
Received: May 10, 2024
Revised: September 29, 2024
Accepted: December 2, 2024
Published online: January 21, 2025
Processing time: 224 Days and 0 Hours
Abstract

Helicobacter pylori-associated gastritis (HPAG) is a common condition of the gastrointestinal tract. However, extensive and long-term antibiotic use has resulted in numerous adverse effects, including increased resistance, gastrointestinal dysfunction, and increased recurrence rates. When these concerns develop, traditional Chinese medicine (TCM) may have advantages. TCM is based on the concept of completeness and aims to eliminate pathogens and strengthen the body. It has the potential to prevent this condition while also boosting the rate of Helicobacter pylori eradication. This review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways, which reflects the flexibility of TCM in treating diseases and the advantages of multi-level, multi-pathway, and multi-target treatments for HPAG.

Keywords: Helicobacter pylori; Helicobacter pylori-associated gastritis; Traditional Chinese medicine; Signalling pathway; Eliminate pathogens; Strengthen the body

Core Tip: Traditional Chinese medicine (TCM) emerges as a promising area for intervention in the face of Helicobacter pylori-associated gastritis (HPAG). In this review, we go over the several signalling mechanisms that TCM uses to influence HAPG. TCM regulates the expression of related genes and proteins through signalling pathways to inhibit inflammatory response, improve oxidative stress, promote gastric mucosal proliferation, avoid epithelial-mesenchymal transition, and prevent cancer. The effect of TCM on HPAG has been observed at multiple levels and pathways. These studies suggest that TCM treatment will become a trend in the treatment of HPAG.