Creeping fat: A promising radiological predictor in small bowel Crohn’s disease

Abstract

In this manuscript, we comment on the article by Hasnaoui et al. Specifically, we delve into the characteristic manifestation of Crohn’s disease (CD) known as creeping fat (CF). Our primary focus is to investigate the potential of imaging features of CF in predicting the response of small bowel CD to biologic therapies and fecal microbiota transplantation. We believe that further research should be dedicated to developing methods for quantifying CF in order to provide more accurate predictive tools for the treatment of small bowel CD.

Keywords: Crohn’s disease; Creeping fat; Biologic agents; Fecal microbiota transplantation; Prediction

Core Tip: Creeping fat is a characteristic manifestation of Crohn’s disease (CD). We explored the relationship between creeping fat and gut microbiota and proposed potential significance of its radiological features in predicting the therapeutic response of small bowel CD to biological therapy and fecal microbiota transplantation. Although further validation is required, these findings can help establish precise predictive tools for CD treatment, thereby guiding personalized therapeutic strategies.