Early diagnostic strategies for colorectal cancer

Abstract

At present, cancer is still an important factor threatening human health. Colorectal cancer (CRC) is one of the top three most common cancers worldwide and one of the deadliest malignancies in humans. The latest data showed that CRC incidence and mortality rank third and second, respectively, among global malignancies. Early and accurate diagnosis is crucial to reduce the morbidity, mortality and improve survival of patients with CRC, but the current early diagnostic methods have limitations. The effectiveness and compliance of diagnostic methods have a certain impact on whether people choose screening. In this editorial, we explore strategies for the early diagnosis of CRC, including stool-based, blood-based, direct visualization, and imaging examinations.

Keywords: Colorectal cancer; Diagnostic markers; Colonoscopy; Fecal immunochemical test; Fecal occult blood test; Circulating tumor cells; Circulating tumor DNA

Core Tip: Colorectal cancer is one of the top three most common cancers worldwide, with high morbidity and mortality. Early and accurate diagnosis is crucial, but the existing diagnostic methods are limited. Stool-based, blood-based, direct visualization and imaging examinations are the current early diagnosis strategies, which should be promoted and improved to decrease morbidity and mortality of patients and improve their prognosis and survival.