Mu T, Lu ZM, Wang WW, Feng H, Jin Y, Ding Q, Wang LF. Helicobacter pylori intragastric colonization and migration: Endoscopic manifestations and potential mechanisms. World J Gastroenterol 2023; 29(30): 4616-4627 [PMID: 37662858 DOI: 10.3748/wjg.v29.i30.4616]
Corresponding Author of This Article
Li-Fen Wang, MD, Associate Chief Physician, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 9677 Jing Shi Road, Jinan 250021, Shandong Province, China. inuonuobao@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 14, 2023; 29(30): 4616-4627 Published online Aug 14, 2023. doi: 10.3748/wjg.v29.i30.4616
Helicobacter pylori intragastric colonization and migration: Endoscopic manifestations and potential mechanisms
Tong Mu, Zhi-Ming Lu, Wen-Wen Wang, Hua Feng, Yan Jin, Qian Ding, Li-Fen Wang
Tong Mu, Wen-Wen Wang, Hua Feng, Qian Ding, Li-Fen Wang, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Zhi-Ming Lu, Yan Jin, Department of Clinical Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Author contributions: Mu T drafted the article; Lu ZM and Jin Y made contributions to the design of the article; Wang WW, Feng H and Ding Q revised the article; Wang LF provides figures, revised the article and made the decision to submit for publication; all authors have read and approved the final manuscript.
Supported byMedical Health Science and Technology Development Plan Project of Shandong Province, No. 202103030765; and Natural Science Foundation of Shandong Province, No. ZR2021QH195 and No. ZR2020QH035.
Conflict-of-interest statement: All authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Fen Wang, MD, Associate Chief Physician, Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 9677 Jing Shi Road, Jinan 250021, Shandong Province, China. inuonuobao@163.com
Received: May 9, 2023 Peer-review started: May 9, 2023 First decision: June 14, 2023 Revised: July 1, 2023 Accepted: July 25, 2023 Article in press: July 25, 2023 Published online: August 14, 2023 Processing time: 92 Days and 22.3 Hours
Abstract
After being ingested and entering the human stomach, Helicobacter pylori (H. pylori) adopts several effective strategies to adhere to and colonize the gastric mucosa and move to different regions of the stomach to obtain more nutrients and escape from the harsher environments of the stomach, leading to acute infection and chronic gastritis, which is the basis of malignant gastric tumors. The endoscopic manifestations and pathological features of H. pylori infection are diverse and vary with the duration of infection. In this review, we describe the endoscopic manifestations of each stage of H. pylori gastritis and then reveal the potential mechanisms of bacterial intragastric colonization and migration from the perspective of endoscopists to provide direction for future research on the effective therapy and management of H. pylori infection.
Core Tip:Helicobacter pylori (H. pylori) adopts several effective strategies to adhere to and colonize the gastric mucosa and move to different regions of the stomach, leading to acute infection and chronic gastritis that can be observed through endoscopy. Herein, we describe the endoscopic manifestations of each stage of H. pylori gastritis and then discuss the potential mechanisms of bacterial intragastric colonization and migration from the perspective of endoscopists to provide direction for future research on the effective therapy and management of H. pylori infection.
