Xu LY, Yu BY, Cen LS. New treatment for gastroesophageal reflux disease: Traditional Chinese medicine Xiaochaihu decoction. World J Gastroenterol 2022; 28(11): 1184-1186 [PMID: 35431502 DOI: 10.3748/wjg.v28.i11.1184]
Corresponding Author of This Article
Lu-Sha Cen, PhD, Attending Doctor, Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. cenlusa2@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Mar 21, 2022; 28(11): 1184-1186 Published online Mar 21, 2022. doi: 10.3748/wjg.v28.i11.1184
New treatment for gastroesophageal reflux disease: Traditional Chinese medicine Xiaochaihu decoction
Li-Ying Xu, Bin-Yan Yu, Lu-Sha Cen
Li-Ying Xu, Department of Emergency Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Bin-Yan Yu, Department of Acupuncture and Moxibustion, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Lu-Sha Cen, Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Author contributions: Xu LY and Cen LS designed the research; Yu BY analyzed the data; Xu LY and Cen LS performed the research and wrote the letter; Cen LS revised the letter.
Supported byScientific Research Project of Zhejiang TCM Science and Technology Programme, No. 2020ZB067, No. 2020ZT001, and No. 2021ZQ031; and National Natural Science Foundation of China, No. 81503522 and No. 82104862.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lu-Sha Cen, PhD, Attending Doctor, Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. cenlusa2@sina.com
Received: August 26, 2021 Peer-review started: August 26, 2021 First decision: September 4, 2021 Revised: September 17, 2021 Accepted: February 23, 2022 Article in press: February 23, 2022 Published online: March 21, 2022 Processing time: 203 Days and 0.8 Hours
Abstract
Gastroesophageal reflux disease (GERD) has a high prevalence worldwide. Li et al performed a well-designed study on the efficacy of modified Xiaochaihu decoction (MXD) for GERD, which showed that MXD is an optional therapy for GERD beyond proton pump inhibitors (PPIs). The herbal granule administration mode minimized the bias from traditional herbal formula in clinical trials. One limitation of that study was that it lacked records of side effects and rescue medication. As a chronic disease with recurrent symptoms, GERD rehabilitation requires prolonged observation of the clinical course with MXD therapy.
Core Tip: Modified Xiaochaihu decoction (MXD) has been applied for gastroesophageal reflux disease (GRED) for thousands of years in Asian countries. Li et al proved that MXD is an ideal optional therapy for GERD. The drug selection of herbal granule makes double-blind research achievable. Side effects of MXD should be noted. As a chronic disease, GERD rehabilitation requires prolonged observation of the clinical course with MXD therapy.
