Li CM, Liu ZC, Bao YT, Sun XD, Wang LL. Extraordinary response of metastatic pancreatic cancer to apatinib after failed chemotherapy: A case report and literature review. World J Gastroenterol 2017; 23(41): 7478-7488 [PMID: 29151702 DOI: 10.3748/wjg.v23.i41.7478]
Corresponding Author of This Article
Lin-Lin Wang, MD, PhD, Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, No. 440, Jiyan Road, Jinan 250117, Shandong Province, China. 13793187739@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
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Li CM, Liu ZC, Bao YT, Sun XD, Wang LL. Extraordinary response of metastatic pancreatic cancer to apatinib after failed chemotherapy: A case report and literature review. World J Gastroenterol 2017; 23(41): 7478-7488 [PMID: 29151702 DOI: 10.3748/wjg.v23.i41.7478]
World J Gastroenterol. Nov 7, 2017; 23(41): 7478-7488 Published online Nov 7, 2017. doi: 10.3748/wjg.v23.i41.7478
Extraordinary response of metastatic pancreatic cancer to apatinib after failed chemotherapy: A case report and literature review
Cheng-Ming Li, Zhi-Chao Liu, You-Ting Bao, Xin-Dong Sun, Lin-Lin Wang
Cheng-Ming Li, Zhi-Chao Liu, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250101, Shandong Province, China
Cheng-Ming Li, Zhi-Chao Liu, You-Ting Bao, Xin-Dong Sun, Lin-Lin Wang, Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China
You-Ting Bao, Department of Oncology, Weifang Medical University, Weifang 261042, Shandong Province, China
Lin-Lin Wang, School of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Li CM collected the case data and wrote the paper; Sun XD and Wang LL treated the patient; Li CM, Liu ZC and Bao YT contributed to the literature search; Wang LL reviewed and revised the manuscript; All authors have read and approved the final manuscript.
Supported by The National Natural Science Foundation of China, No. 81402299; the Project of Postdoctoral Innovation of Shandong Province, No. 201501010; and the Project of Postdoctoral Science Foundation of China, No. 2016M590640.
Institutional review board statement: The case report was reviewed and approved by the Institutional Review Board of Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.
Informed consent statement: The husband of the patient provided written informed consent.
Conflict-of-interest statement: All the authors declare that there is no conflict of interest.
Data sharing statement: No additional data are available.
Correspondence to: Lin-Lin Wang, MD, PhD, Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, No. 440, Jiyan Road, Jinan 250117, Shandong Province, China. 13793187739@163.com
Telephone: +86-531-67626142 Fax: +86-531-67626141
Received: July 14, 2017 Peer-review started: August 1, 2017 First decision: August 31, 2017 Revised: September 13, 2017 Accepted: September 26, 2017 Article in press: September 26, 2017 Published online: November 7, 2017 Processing time: 96 Days and 10 Hours
Abstract
Chemotherapy has limited efficacy in the treatment of advanced and metastatic pancreatic cancer (PC), and has serious side effects. The development of novel effective agents, especially targeted therapy, is essential for patients with PC. We present a 58-year-old Chinese woman initially diagnosed with locally advanced PC. As the disease progressed to Stage IV, the patient was unable to tolerate chemotherapy after the fourth-line treatment. She was then treated with apatinib, a novel and highly selective tyrosine kinase inhibitor of vascular endothelial growth factor receptor-2 and achieved a progression-free-survival of 7 mo. All drug-related side effects were well controlled with medication. To the best of our knowledge, this is the first case of PC which responded to apatinib. Considering this remarkable response, apatinib may be a promising agent in the treatment of PC. We also reviewed the literature on chemotherapy and targeted therapy, especially the anti-angiogenesis therapy for patients with PC, and investigated the effect of apatinib in other solid tumors as well.
Core tip: As chemotherapy has limited efficacy in the treatment of advanced and metastatic pancreatic cancer, targeted therapy is becoming increasingly important in patients with pancreatic cancer. The case reported herein suggests that apatinib, a novel and highly selective tyrosine kinase inhibitor of vascular endothelial growth factor receptor-2, may be a promising and useful agent in the treatment of pancreatic cancer.
