Risk factors for tuberculosis after gastrectomy in gastric cancer

doi:10.3748/wjg.v22.i8.2585

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 22, Issue 8

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (10069)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-4) series.

Item

Count

PDF

613

WORD

394

HTML

4033

Tables (1-4)

509

Sum=5549

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1470

Download

3053

Sum=4523

Feb 28, 2016 (publication date) through Feb 23, 2026

Times Cited of This Article

Times Cited (11)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Retrospective Cohort Study

World J Gastroenterol. Feb 28, 2016; 22(8): 2585-2591
Published online Feb 28, 2016. doi: 10.3748/wjg.v22.i8.2585

Risk factors for tuberculosis after gastrectomy in gastric cancer

Won Jai Jung, Young Mok Park, Joo Han Song, Kyung Soo Chung, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Sung Hoon Noh, Ji Yeong An, Young Ae Kang

Won Jai Jung, Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Seoul 120-752, South Korea

Young Mok Park, Joo Han Song, Kyung Soo Chung, Song Yee Kim, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Young Ae Kang, Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Institute of Chest Diseases, Yonsei University College of Medicine, Seoul 120-752, South Korea

Sung Hoon Noh, Ji Yeong An, Department of Surgery, Yonsei University College of Medicine, Seoul 120-752, South Korea

Author contributions: Jung WJ, An JY and Kang YA designed the research; Jung WJ and Park YM wrote the paper; Song JH, Kim SY, Kim EY and Noh SH acquired the data; Jung WJ, Chung KS, Jung JY and Park MS analyzed the data; Kim YS, Kim SK, Chang J, An JY and Kang YA reviewed and edited the paper; An JY and Kang YA contributed equally to this article; All authors read and approved the final manuscript.

Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Severance Hospital (IRB No. 4-2014-0506).

Conflict-of-interest statement: None of the authors has a conflict of interest.

Data sharing statement: The technical appendix, statistical codes, and dataset are available from the corresponding author at mdkang@yuhs.ac. Consent was not obtained but the data presented were anonymized; thus, the risk of identification is low.

Correspondence to: Young Ae Kang, MD, Department of Internal Medicine, Severance Hospital, Institute of Chest Diseases, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, South Korea. mdkang@yuhs.ac

Telephone: +82-2-22281986 Fax: +82-2-3936884

Received: July 2, 2015
Peer-review started: July 6, 2015
First decision: July 19, 2015
Revised: September 18, 2015
Accepted: November 30, 2015
Article in press: December 1, 2015
Published online: February 28, 2016
Processing time: 238 Days and 18.6 Hours

Abstract

AIM: To examine incidence of tuberculosis (TB) in gastrectomy patients and investigate the risk factors for developing TB after gastrectomy in patients with gastric cancer.

METHODS: A retrospective cohort study of gastrectomy patients with gastric cancer was performed at a university-affiliated hospital in Seoul, South Korea between January 2007 and December 2009. We reviewed patient medical records and collected data associated with the risk of TB, surgery, and gastric cancer. Standardized incidence ratios (SIRs) of TB were calculated to compare the incidence of TB in gastrectomy patients with that in the general Korean population, and risk factors for TB after gastrectomies were analyzed.

RESULTS: Among the 1776 gastrectomy patients, 0.9% (16/1776) developed post-gastrectomy TB, with an incidence of 223.7 cases per 100000 patients per year. The overall incidence of TB in gastrectomy patients, adjusted by sex and age, was significantly higher than that in the general population (SIR = 2.22, 95%CI: 1.27-3.60). Previous TB infection [odds ratio (OR) = 7.1, P < 0.001], lower body mass index (BMI) (kg/m²; OR = 1.21, P = 0.043) and gastrectomy extent (total gastrectomy vs subtotal gastrectomy) (OR = 3.48, P = 0.017) were significant risk factors for TB after gastrectomy in a multivariate analysis.

CONCLUSION: TB incidence after gastrectomy is higher than that in the general population. Previous TB infection, lower BMI, and total gastrectomy are risk factors for TB after gastrectomy in patients with gastric cancer.

Keywords: Tuberculosis; Gastrectomy; Body mass index; Risk factor; Gastric cancer

Core tip: The incidence of tuberculosis (TB) in patients who underwent gastrectomy was found to be more than two-times higher than that in the general population. Also, we found that a previous TB infection [odds ratio (OR) = 7.1, P < 0.001], gastrectomy extent (total gastrectomy vs subtotal gastrectomy) (OR = 3.48, P = 0.017) and lower body mass index (kg/m²; OR = 1.21, P = 0.043) were significant risk factors for TB after gastrectomy in gastric cancer.