Glutathione S-transferase M1 polymorphism and esophageal cancer risk: An updated meta-analysis based on 37 studies

doi:10.3748/wjg.v22.i5.1911

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 22, Issue 5

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (10592)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-2) series.

Item

Count

PDF

599

WORD

397

HTML

4617

Figures (1-2)

511

Tables (1-2)

592

Sum=6716

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1298

Download

2561

Sum=3859

Feb 7, 2016 (publication date) through Feb 20, 2026

Times Cited of This Article

Times Cited (7)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Meta-Analysis

World J Gastroenterol. Feb 7, 2016; 22(5): 1911-1918
Published online Feb 7, 2016. doi: 10.3748/wjg.v22.i5.1911

Glutathione S-transferase M1 polymorphism and esophageal cancer risk: An updated meta-analysis based on 37 studies

Quan-Jun Lu, Ya-Cong Bo, Yan Zhao, Er-Jiang Zhao, Wolde Bekalo Sapa, Ming-Jie Yao, Dan-Dan Duan, Yi-Wei Zhu, Wei-Quan Lu, Ling Yuan

Quan-Jun Lu, Ya-Cong Bo, Wolde Bekalo Sapa, Dan-Dan Duan, Yi-Wei Zhu, Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China

Yan Zhao, Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China

Er-Jiang Zhao, Wei-Quan Lu, Affiliated Tumor Hospital of Zhengzhou University, Henan Tumor Hospital, Zhengzhou 450003, Henan Province, China

Ming-Jie Yao, School of Basic Medical Sciences, Peking University, Beijing 100191, China

Ling Yuan, Department of Radiotherapy, Affiliated Tumor Hospital of Zhengzhou University, Henan Tumor Hospital, Zhengzhou 450003, Henan Province, China

Author contributions: Lu QJ, Lu WQ and Yuan L conceived and designed the study; Bo YC, Zhao Y, Zhao EJ, Duan DD and Zhu YW selected the studies, extracted the data and performed the statistical analysis; Lu QJ and Bo YC drafted the manuscript; Sapa WB and Yao MJ revised the manuscript.

Supported by Science and Technology Project of The Health Department of Henan Province, China, No. 510102050432.

Conflict-of-interest statement: The authors declare that there are no conflicts of interest.

Data sharing statement: No additional data are available.

Correspondence to: Ling Yuan, MD, Department of Radiotherapy, Affiliated Tumor Hospital of Zhengzhou University, Henan Tumor Hospital, No. 1 Jianshe East Rd, Erqi District, Zhengzhou 450003, Henan Province, China. hnyl2001@126.com

Telephone: +86-371-67781868 Fax: +86-371-67781868

Received: March 31, 2015
Peer-review started: April 1, 2015
First decision: June 19, 2015
Revised: October 6, 2015
Accepted: November 13, 2015
Article in press: November 13, 2015
Published online: February 7, 2016
Processing time: 295 Days and 17.4 Hours

Abstract

AIM: To evaluate the relationship between glutathione S-transferase M1 (GSTM1) polymorphism and susceptibility to esophageal cancer (EC).

METHODS: A comprehensive search of the United States National Library of Medicine PubMed database and the Elsevier, Springer, and China National Knowledge Infrastructure databases for all relevant studies was conducted using combinations of the following terms: “glutathione S-transferase M1”, “GSTM1”, “polymorphism”, and “EC” (until November 1, 2014). The statistical analysis was performed using the SAS software (v.9.1.3; SAS Institute, Cary, NC, United States) and the Review Manager software (v.5.0; Oxford, England); crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between the GSTM1 null genotype and the risk of EC.

RESULTS: A total of 37 studies involving 2236 EC cases and 3243 controls were included in this meta-analysis. We observed that the GSTM1 null genotype was a significant risk factor for EC in most populations (OR = 1.33, 95%CI: 1.12-1.57, P_{heterogeneity} < 0.000001, and I² = 77.0%), particularly in the Asian population (OR = 1.53, 95%CI: 1.26-1.86, P_{heterogeneity} < 0.000001, and I² = 77.0%), but not in the Caucasian population (OR = 1.02, 95%CI: 0.87-1.19, P_{heterogeneity} = 0.97, and I² = 0%).

CONCLUSION: The GSTM1 null polymorphism may be associated with an increased risk for EC in Asian but not Caucasian populations.

Keywords: Meta-analysis; Glutathione S-transferase M1; Polymorphism; Esophageal cancer; Deletions

Core tip: Many previous studies have investigated the association between the glutathione S-transferase M1 (GSTM1) null genotype and the risk of esophageal cancer (EC), but these studies have provided controversial findings. The present study represents the largest meta-analysis to estimate the association between the GSTM1 polymorphism and EC risk. We investigated these two genotypes (GSTM1 null or GSTM1 present) in terms of EC morbidity.