Published online Sep 14, 2016. doi: 10.3748/wjg.v22.i34.7787
Peer-review started: April 21, 2016
First decision: May 12, 2016
Revised: May 20, 2016
Accepted: June 15, 2016
Article in press: June 15, 2016
Published online: September 14, 2016
Processing time: 142 Days and 0.2 Hours
To compare 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) features in gastric lymphoma and gastric carcinoma.
Patients with newly diagnosed gastric lymphoma or gastric carcinoma who underwent 18F-FDG PET/CT prior to treatment were included in this study. We reviewed and analyzed the PET/CT features of gastric wall lesions, including FDG avidity, pattern (focal/diffuse), and intensity [maximal standard uptake value: (SUVmax)]. The correlation of SUVmax with gastric clinicopathological variables was investigated by χ2 test, and receiver-operating characteristic (ROC) curve analysis was performed to determine the differential diagnostic value of SUVmax-associated parameters in gastric lymphoma and gastric carcinoma.
Fifty-two patients with gastric lymphoma and 73 with gastric carcinoma were included in this study. Abnormal gastric FDG accumulation was found in 49 patients (94.23%) with gastric lymphoma and 65 patients (89.04%) with gastric carcinoma. Gastric lymphoma patients predominantly presented with type I and type II lesions, whereas gastric carcinoma patients mainly had type III lesions. The SUVmax (13.39 ± 9.24 vs 8.35 ± 5.80, P < 0.001) and SUVmax/THKmax (maximal thickness) (7.96 ± 4.02 vs 4.88 ± 3.32, P < 0.001) were both higher in patients with gastric lymphoma compared with gastric carcinoma. ROC curve analysis suggested a better performance of SUVmax/THKmax in the evaluation of gastric lesions between gastric lymphoma and gastric carcinoma in comparison with that of SUVmax alone.
PET/CT features differ between gastric lymphoma and carcinoma, which can improve PET/CT evaluation of gastric wall lesions and help differentiate gastric lymphoma from gastric carcinoma.
Core tip:18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) feature in gastric lymphomas compared to that in gastric carcinomas were investigated. Gastric lymphoma patients predominantly presented with type I and type II lesions, whereas gastric carcinoma patients mainly with type III lesions. The SUVmax and SUVmax/THKmax were both higher in patients with gastric lymphomas compared to that in patients with gastric carcinomas. A ROC curve analysis suggested a better performance of SUVmax/THKmax in the evaluation of gastric lesions in comparison with that of SUVmax alone. The differences existed in the PET/CT feature could improve the PET/CT evaluation of gastric lesions and contribute to the identification of gastric lymphomas from gastric carcinomas.