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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Retrospective analysis of extra-gastrointestinal stromal tumors
Jun Ho Yi, Byeong-Bae Park, Jung Hun Kang, In Gyu Hwang, Dong Bok Shin, Sun Jin Sym, Hee Kyung Ahn, Soon Il Lee, Do Hyoung Lim, Keon Woo Park, Young-Woong Won, Sung Hee Lim, Se Hoon Park
Jun Ho Yi, Byeong-Bae Park, Division of Hematology-Oncology, Department of Internal Medicine, Hanyang University Seoul Hospital, Seoul 133-792, South Korea
Jung Hun Kang, Division of Hematology-Oncology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju 660-702, South Korea
In Gyu Hwang, Division of Hematology-Oncology, Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 156-755, South Korea
Dong Bok Shin, Sun Jin Sym, Hee Kyung Ahn, Division of Hematology-Oncology, Department of Internal Medicine, Gachon University Gil Hospital, Incheon 405-760, South Korea
Soon Il Lee, Do Hyoung Lim, Keon Woo Park, Department of Hematology-Oncology, Dankook University School of Medicine, Cheonan 330-715, South Korea
Young-Woong Won, Division of Hematology and Oncology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri 471-701, South Korea
Sung Hee Lim, Se Hoon Park, Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University Samsung Medical Center, Cancer hospital, Seoul 135-710, South Korea
Author contributions: Yi JH, Kang JH, Hwang IG, Ahn HK, Lee SI, Lim DH, Won YW and Park SH designed the research; Yi JH, Park BB, Shin DB, Sym SJ and Park KW performed the research; Kang JH, Ahn HK and Lim SH analyzed the data; Yi JH, Won YW and Park SH wrote the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Se Hoon Park, MD, Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University Samsung Medical Center, Cancer hospital, 10
th floor, Faculty office, Seoul 135-710, South Korea.
hematoma@skku.edu
Telephone: +82-2-34101767
Received: May 27, 2014
Peer-review started: May 31, 2014
First decision: July 9, 2014
Revised: September 4, 2014
Accepted: October 14, 2014
Article in press: October 15, 2014
Published online: February 14, 2015
Processing time: 260 Days and 5.7 Hours
AIM: To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors (EGISTs) in South Korea.
METHODS: A total of 51 patients with an EGIST were identified. The clinicopathologic features, including sex, age, location, tumor size, histology, mitotic rate, immunohistochemical features, genetic status and survival data, were analyzed.
RESULTS: The median age was 55 years (range: 29-80 years), and male:female ratio was 1:1.04. The most common site was in the mesentery (n = 15) followed by the retroperitoneum (n = 13) and omentum (n = 8). The median tumor size was 9.0 cm (range: 2.6-30.0 cm) and the median mitotic rate was 5.0/50HPF. (1/50 - 185/50). KIT was analyzed in 16, which revealed 10 cases with wild-type KIT and 6 cases with an exon 11 mutation. Among 51 patients, 31 patients had undergone surgery, and 10 had unresectable disease and had taken palliative imatinib, which resulted in 22.7 mo of progression-free survival. Of the patients who had undergone surgery, 18 did not take adjuvant imatinib, and 8 of these were categorized as “high risk” according to the risk criteria. However, the relapse-free survival was not different (P = 0.157) between two groups.
CONCLUSION: Because the biologic behaviors of GISTs differ according to the location of the tumor, a more stratified strategy is required for managing EGISTs including incorporation of molecular features.
Core tip: A gastrointestinal stromal tumor arising outside the gastrointestinal tract is called an extra-gastrointestinal stromal tumor (EGIST). In this study, we analyzed 51 patients with an EGIST and found that, patients with an EGIST have unique clinicopathologic features and distinct disease courses. Therefore, the risk stratification of this disease should be distinguished from that of GISTs.
