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World J Gastroenterol. Mar 7, 2014; 20(9): 2200-2211
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2200
Endoscopic innovations to increase the adenoma detection rate during colonoscopy
Vincent K Dik, Leon MG Moons, Peter D Siersema
Vincent K Dik, Leon MG Moons, Peter D Siersema, Department of Gastroenterology and Hepatology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
Author contributions: Dik VK drafted the manuscript; Dik VK, Moons LMG and Siersema PD contributed to critical revision of the manuscript for important intellectual content; Moons LMG and Siersema PD contributed to supervision; All authors approved the final manuscript.
Correspondence to: Peter D Siersema, Professor, Department of Gastroenterology and Hepatology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands. p.d.siersema@umcutrecht.nl
Telephone: +31-88-7559338 Fax: +31-88-7555533
Received: October 27, 2013
Revised: December 6, 2013
Accepted: January 19, 2014
Published online: March 7, 2014
Processing time: 129 Days and 21.1 Hours
Abstract

Up to a quarter of polyps and adenomas are missed during colonoscopy due to poor visualization behind folds and the inner curves of flexures, and the presence of flat lesions that are difficult to detect. These numbers may however be conservative because they mainly come from back-to-back studies performed with standard colonoscopes, which are unable to visualize the entire mucosal surface. In the past several years, new endoscopic techniques have been introduced to improve the detection of polyps and adenomas. The introduction of high definition colonoscopes and visual image enhancement technologies have been suggested to lead to better recognition of flat and small lesions, but the absolute increase in diagnostic yield seems limited. Cap assisted colonoscopy and water-exchange colonoscopy are methods to facilitate cecal intubation and increase patients comfort, but show only a marginal or no benefit on polyp and adenoma detection. Retroflexion is routinely used in the rectum for the inspection of the dentate line, but withdrawal in retroflexion in the colon is in general not recommended due to the risk of perforation. In contrast, colonoscopy with the Third-Eye Retroscope® may result in considerable lower miss rates compared to standard colonoscopy, but this technique is not practical in case of polypectomy and is more time consuming. The recently introduced Full Spectrum Endoscopy™ colonoscopes maintains the technical capabilities of standard colonoscopes and provides a much wider view of 330 degrees compared to the 170 degrees with standard colonoscopes. Remarkable lower adenoma miss rates with this new technique were recently demonstrated in the first randomized study. Nonetheless, more studies are required to determine the exact additional diagnostic yield in clinical practice. Optimizing the efficacy of colorectal cancer screening and surveillance requires high definition colonoscopes with improved virtual chromoendoscopy technology that visualize the whole colon mucosa while maintaining optimal washing, suction and therapeutic capabilities, and keeping the procedural time as low and patient discomfort as optimal as possible.

Keywords: Colonoscopy; Endoscopic innovations; Adenoma detection; Polyp detection; Gastrointestinal endoscopy

Core tip: Up to a quarter of polyps and adenomas are missed during colonoscopy due to poor visualization behind folds and the inner curves of flexures, and the presence of flat lesions that are difficult to detect. In the past several years, new endoscopic techniques have been introduced to improve the detection of polyps and adenomas. Optimizing the efficacy of colorectal cancer screening and surveillance requires high definition colonoscopes with improved virtual chromoendoscopy technology that visualize the whole colon mucosa while maintaining optimal washing, suction and therapeutic capabilities, and keeping the procedural time as low and patient discomfort as optimal as possible.