Retrospective Study
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World J Gastroenterol. Sep 21, 2014; 20(35): 12595-12601
Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12595
Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: A single-center experience
Fu-Bo Zhang, Ai-Min Zhang, Zhi-Bin Zhang, Xin Huang, Xi-Tao Wang, Jia-Hong Dong
Fu-Bo Zhang, Ai-Min Zhang, Zhi-Bin Zhang, Xin Huang, Xi-Tao Wang, Jia-Hong Dong, Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China
Fu-Bo Zhang, Ai-Min Zhang, Zhi-Bin Zhang, Xin Huang, Xi-Tao Wang, Jia-Hong Dong, Medical School, Nankai University, Tianjin 300071, China
Ai-Min Zhang, Department of Tuberculosis, Binzhou Center Hospital, Binzhou 251700, Shandong Province, China
Author contributions: Dong JH designed the research; Zhang FB, Zhang AM, Zhang ZB performed the research; Huang X, Wang XT contributed new reagents or analytic tools; Zhang FB, Huang X, Wang XT analyzed the data; Zhang FB, Zhang AM, Zhang ZB, Huang X, Wang XT and Dong JH wrote the paper.
Correspondence to: Jia-Hong Dong, MD, Department of Hepatobiliary Surgery, Chinese PLA General Hospital, 28th Fuxing Rd, Beijing 100853, China. 251809@163.com
Telephone: +86-10-66876432 Fax: +86-10-66876432
Received: March 19, 2014
Revised: May 19, 2014
Accepted: June 14, 2014
Published online: September 21, 2014
Processing time: 184 Days and 19.3 Hours
Abstract

AIM: To investigate preoperative differential diagnoses made between intrahepatic biliary cystadenoma and intrahepatic biliary cystadenocarcinoma.

METHODS: A retrospective analysis of patient data was performed, which included 21 cases of intrahepatic biliary cystadenoma and 25 cases of intrahepatic biliary cystadenocarcinoma diagnosed between April 2003 and April 2013 at the General Hospital of PLA. Potential patients were excluded whose diagnoses were not confirmed pathologically. Basic information (including patient age and gender), clinical manifestation, duration of symptoms, serum assay results (including tumor markers and the results of liver function tests), radiological features and pathological results were collected. All patients were followed up.

RESULTS: Preoperative levels of cancer antigen 125 (12.51 ± 9.31 vs 23.20 ± 21.86, P < 0.05) and carbohydrate antigen 19-9 (22.56 ± 26.30 vs 72.55 ± 115.99, P < 0.05) were higher in the cystadenocarcinoma subgroup than in the cystadenoma subgroup. There were no statistically significant differences in age or gender between the two groups, or in pre- or post-operative levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin (TBIL), and direct bilirubin (DBIL) between the two groups. However, eight of the 21 patients with cystadenoma and six of the 25 patients with cystadenocarcinoma had elevated levels of TBIL and DBIL. There were three cases in the cystadenoma subgroup and six cases in the cystadenocarcinoma subgroup with postoperative complications.

CONCLUSION: Preoperative differential diagnosis relies on the integration of information, including clinical symptoms, laboratory findings and imaging results.

Keywords: Intrahepatic biliary cystadenoma; Intrahepatic biliary cystadenocarcinoma; Preoperative differential diagnosis

Core tip: The number of females was larger than that of males in both groups. Carbohydrate antigen 19-9 has important significance in the preoperative diagnosis of intrahepatic biliary cystadenoma and cystadenocarcinoma. About half of the patients had elevated levels of total bilirubin (TBIL) and direct bilirubin (DBIL); therefore, we believe it is necessary to test TBIL and DBIL before surgery. The diagnosis relies on the integration of information consisting of clinical symptoms, laboratory findings and imaging results. The short-term and long-term prognoses of cystadenoma were better than those for cystadenocarcinoma.