Published online Mar 25, 1996. doi: 10.3748/wjg.v2.i1.51
Revised: January 20, 1996
Accepted: February 13, 1996
Published online: March 25, 1996
AIM: To evaluate multiparameter histologic diagnosis of gastric cancer (GC).
METHODS: Expression of the MGa23c7 antigen and the cerbBa22 receptor was detected in specimens of GC by ABC immunohistochemistry. The DNA content of specimens was determined by flow cytometry (FCM). The data of the multiparameter methodology were analyzed statistically.
RESULTS: The expression rates of MGa23c7 antigen and cerbBa22 receptor were observed in gastric tubular adenocarcinoma (GTA; 100% and 56% respectively), adenocarcinoma (AC; 58% and 50%) and normal gastric mucosa (NGM; 20% and 33%). The DNA heteroploid rate was 63% (12/19) in GTA, 75% (3/4) in AC and 0% (0/8) in NGM. In detecting GTA with FCM and the ABC method, the histological parameter analysis showed that sensitivity was 82% ± 3%, specificity was 88%, predictive value was 95% ± 4% and accuracy was 84%. Both methods were complementary.
CONCLUSION: Multiparameter diagnosis and studies of histomorphology and molecular biology may be a useful approach towards histologic diagnosis of GC.