Cha BH, Hwang JH, Lee SH, Kim JE, Cho JY, Kim H, Kim SY. Pre-operative factors that can predict neoplastic polypoid lesions of the gallbladder. World J Gastroenterol 2011; 17(17): 2216-2222 [PMID: 21633532 DOI: 10.3748/wjg.v17.i17.2216]
Corresponding Author of This Article
Sang Hyub Lee, MD, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, South Korea. gidoctor@snubh.org
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World J Gastroenterol. May 7, 2011; 17(17): 2216-2222 Published online May 7, 2011. doi: 10.3748/wjg.v17.i17.2216
Pre-operative factors that can predict neoplastic polypoid lesions of the gallbladder
Byung Hyo Cha, Jin-Hyeok Hwang, Sang Hyub Lee, Jang Eon Kim, Jai Young Cho, Haeryoung Kim, So Yeon Kim
Byung Hyo Cha, Department of Internal Medicine, Cheju Halla General Hospital, Cheju-si, Cheju-do 690-766, South Korea
Jin-Hyeok Hwang, Sang Hyub Lee, Jang Eon Kim, Departments of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Geonggi-do 463-707, South Korea
Jai Young Cho, Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Geonggi-do 463-707, South Korea
Haeryoung Kim, Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Geonggi-do 463-707, South Korea
So Yeon Kim, Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Geonggi-do 463-707, South Korea
Author contributions: Cha BH and Lee SH performed the majority of experiments; Cha BH, Hwang JH, Lee SH and Kim JE designed the research; Hwang JH, Lee SH, Kim JE, Cho JY, Kim H and Kim SY collected human material and were involved in editing the manuscript; Cha BH analyzed the data and wrote the manuscript.
Correspondence to: Sang Hyub Lee, MD, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, South Korea. gidoctor@snubh.org
Telephone: +82-31-7877042 Fax: +82-31-7877051
Received: October 27, 2010 Revised: November 30, 2010 Accepted: December 7, 2010 Published online: May 7, 2011
Abstract
AIM: To investigate the preoperative factors that can predict neoplastic polypoid lesions of the gallbladder (PLGs) as well as malignant PLGs.
METHODS: A retrospective analysis was conducted on the 210 consecutively enrolled patients who underwent cholecystectomy due to a PLG larger than 10 mm, as was determined by preoperative trans-abdominal ultrasonography or endoscopic ultrasonography. We analyzed the medical, laboratory, radiologic data and the pathologic results.
RESULTS: In 210 cases, 146 had non-neoplastic polyps (69.5%) and 64 cases were neoplastic polyps (30.5%). An older age (≥ 65 years), the presence of diabetes mellitus (DM) and the size of polyp (≥ 15 mm) were revealed to be independent predictive variables for neoplastic polyps with odd ratios (OR) of 2.27 (P = 0.044), 2.64 (P = 0.021) and 4.94 (P < 0.01), respectively. Among the neoplastic PLGs, an older age (≥ 65 years), the presence of DM and polyp size (≥ 15 mm) were associated with malignancy with ORs of 4.97 (P = 0.005), 6.13 (P = 0.001) and 20.55 (P < 0.001), respectively.
CONCLUSION: Among patients with PLGs larger than 10 mm in size, higher risk groups such as elderly patients more than 65 years old, those with DM or a large polyp size (≥ 15 mm) should be managed by cholecystectomy.
