Brief Article
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World J Gastroenterol. Sep 14, 2010; 16(34): 4348-4356
Published online Sep 14, 2010. doi: 10.3748/wjg.v16.i34.4348
Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: A meta-analysis
Wei-Guo Lu, Yan-Feng Zou, Xiao-Liang Feng, Feng-Lai Yuan, Yuan-Long Gu, Xia Li, Cheng-Wan Li, Cheng Jin, Jian-Ping Li
Wei-Guo Lu, Feng-Lai Yuan, Xia Li, Department of Clinical Pharmacology, The Third Hospital Affiliated to Nantong University, Wuxi 214041, Jiangsu Province, China
Yan-Feng Zou, Xiao-Liang Feng, Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, Anhui Province, China
Yuan-Long Gu, Cheng-Wan Li, Cheng Jin, Jian-Ping Li, Department of Hepatobiliary Pancreatic Center, The Third Hospital Affiliated to Nantong University, Wuxi 214041, Jiangsu Province, China
Author contributions: Lu WG, Li JP and Zou YF designed the study, did data interpretation, and wrote the manuscript; Feng XL, Yuan FL, Gu YL and Li X performed the majority of data analysis; Li CW and Jin C were involved in the study design.
Supported by The National Natural Science Foundation of China (30972530)
Correspondence to: Jian-Ping Li, MD, PhD, Department of Hepatobiliary Pancreatic Center, The Third Hospital Affiliated to Nantong University, Wuxi 214041, Jiangsu Province, China. wxsyljp@163.com
Telephone: +86-510-82607561 Fax: +86-510-82607561
Received: March 29, 2010
Revised: April 20, 2010
Accepted: April 27, 2010
Published online: September 14, 2010
Abstract

AIM: To find evidences about whether NOD1/CARD4 insertion/deletion polymorphism is associated with inflammatory bowel disease by meta-analysis.

METHODS: We surveyed the studies on the association of NOD1/CARD4 insertion/deletion polymorphism with inflammatory bowel disease in PubMed. Meta-analysis was performed for genotypes GG/T vs T/T, GG/GG vs T/T, GG/T + GG/GG vs T/T, GG/GG vs T/T + GG/T, and GG allele vs T allele in a fixed/random effect model.

RESULTS: We identified 8 studies (6439 cases and 4798 controls) in Caucasian populations using PubMed search. We found no association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease, Crohn’s disease, and ulcerative colitis. Stratification of cases by age showed that NOD1/CARD4 insertion/deletion polymorphism was associated with inflammatory bowel disease in younger age group at onset (< 40 years) (GG vs T: OR = 0.68, 95% CI: 0.50-0.93, P = 0.02; GG/T + GG/GG vs T/T: OR = 0.71, 95% CI: 0.59-0.85, P = 0.0003).

CONCLUSION: This meta-analysis demonstrates an association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease in the younger age group at onset (< 40 years) in Caucasian populations.

Keywords: NOD1; CARD4; Genetic polymorphisms; Inflammatory bowel disease; Meta-analysis