Case Report
Copyright ©2010 Baishideng. All rights reserved.
World J Gastroenterol. May 7, 2010; 16(17): 2183-2186
Published online May 7, 2010. doi: 10.3748/wjg.v16.i17.2183
Refractory gastric ulcer with abundant IgG4-positive plasma cell infiltration: A case report
Takayoshi Fujita, Takafumi Ando, Masatoshi Sakakibara, Waki Hosoda, Hidemi Goto
Takayoshi Fujita, Masatoshi Sakakibara, Department of Gastroenterology, Aichi Cancer Center Aichi Hospital, Okazaki City, Aichi 444-0011, Japan
Takafumi Ando, Hidemi Goto, Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya City, Aichi 466-8550, Japan
Waki Hosoda, Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya City, Aichi 464-8681, Japan
Author contributions: Fujita T and Sakakibara M saw the patient; Hosoda W worked on the pathological study; Fujita T, Sakakibara M, Ando T and Goto H worked on the treatment decision; Fujita T, Ando T and Goto H wrote the paper.
Correspondence to: Takafumi Ando, MD, PhD, Associate Professor, Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya City, Aichi 466-8550, Japan. takafumiando-gi@umin.ac.jp
Telephone: +81-52-7442144 Fax: +81-52-7442175
Received: December 11, 2009
Revised: February 4, 2010
Accepted: February 11, 2010
Published online: May 7, 2010
Abstract

We describe a 77-year-old man with refractory gastric ulcer that worsened after Helicobacter pylori eradication therapy. Pathology showed marked infiltration of IgG4-positive plasma cells in the gastric lesions, which led us to suspect IgG4-related sclerosing disease. To the best of our knowledge, this is the first report of IgG4-related gastric ulcer without the main manifestation of autoimmune pancreatitis.

Keywords: Sclerosis; Gastric ulcer; IgG4; Plasma cells