Kim MS, Cho CK, Yang KM, Lee DH, Moon SM, Shin YJ. Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer. World J Gastroenterol 2009; 15(48): 6091-6095 [PMID: 20027683 DOI: 10.3748/wjg.15.6091]
Corresponding Author of This Article
Mi-Sook Kim, MD, PhD, Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, South Korea. mskim@kcch.re.kr
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Brief Article
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World J Gastroenterol. Dec 28, 2009; 15(48): 6091-6095 Published online Dec 28, 2009. doi: 10.3748/wjg.15.6091
Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer
Mi-Sook Kim, Chul Koo Cho, Kwang Mo Yang, Dong Han Lee, Sun Mi Moon, Young Joo Shin
Mi-Sook Kim, Chul Koo Cho, Kwang Mo Yang, Dong Han Lee, Sun Mi Moon, Young Joo Shin, Department of Radiation Oncology and Surgery, Korea Institute of Radiological & Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, South Korea
Author contributions: Kim MS and Shin YJ wrote the manuscript; Kim MS, Cho CK, Yang KM, Lee DH and Moon SM took part in management of the treatment and provided the clinical data; all the authors discussed the patient’s outcomes and commented on the manuscript.
Supported by The National Nuclear Research and Development Program of the Ministry of Education, Science and Technology, South Korea
Correspondence to: Mi-Sook Kim, MD, PhD, Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, South Korea. mskim@kcch.re.kr
Telephone: +82-2-9701264 Fax: +82-2-9702412
Received: June 17, 2009 Revised: August 24, 2009 Accepted: August 31, 2009 Published online: December 28, 2009
Abstract
AIM: To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer.
METHODS: From 2003 to 2009, 7 patients with paraaortic lymph node recurrence (1-3 lesions) from colorectal cancer were treated with stereotactic body radiotherapy. Total gross tumor volumes ranged from 4 to 40 mL. The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions.
RESULTS: One and 3 year overall survival rates were 100% and 71.4%, respectively, and median survival was 37 mo. Grade IV intestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy = 3.6 mL. However, 6 patients received an intestinal maximum point dose of < 51 Gy and V45Gy of < 1 mL, and did not develop any severe complications.
CONCLUSION: This pilot study suggests selected paraaortic lymph node recurrence (1-3 closed lesions) that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy.
