Choi D, Lee HW, Hur KY, Kim JJ, Park GS, Jang SH, Song YS, Jang KS, Paik SS. Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma. World J Gastroenterol 2009; 15(18): 2258-2264 [PMID: 19437567 DOI: 10.3748/wjg.15.2258]
Corresponding Author of This Article
Seung Sam Paik, Department of Pathology, College of Medicine, Hanyang University, Seoul, South Korea. sspaik@hanyang.ac.kr
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Brief Articles
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World J Gastroenterol. May 14, 2009; 15(18): 2258-2264 Published online May 14, 2009. doi: 10.3748/wjg.15.2258
Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma
Dongho Choi, Hyo Won Lee, Kyung Yul Hur, Jae Joon Kim, Gyeong-Sin Park, Si-Hyong Jang, Young Soo Song, Ki-Seok Jang, Seung Sam Paik
Dongho Choi, Kyung Yul Hur, Jae Joon Kim, Department of Surgery, College of Medicine, Soonchunhyang University, 140-743 Seoul, South Korea
Hyo Won Lee, Department of Surgery, Chi Hang Hospital, 140-741 Seoul, South Korea
Gyeong-Sin Park, Department of Pathology, College of Medicine, Catholic University, 137-040 Seoul, South Korea
Si-Hyong Jang, Young Soo Song, Ki-Seok Jang, Seung Sam Paik, Department of Pathology, College of Medicine, Hanyang University, 133-790 Seoul, South Korea
Author contributions: Choi D and Lee HW contributed equally to this work; Choi D and Lee HW designed the study and wrote the manuscript; Hur KY and Kim JJ were involved in editing the manuscript; Park GS provided vital reagents; Jang SH and Jang KS provided all the human material, and performed the majority of the experiments and statistical analysis of the data; Song YS and Paik SS interpreted the immunohistochemical results.
Correspondence to: Seung Sam Paik, Department of Pathology, College of Medicine, Hanyang University, Seoul, South Korea. sspaik@hanyang.ac.kr
Telephone: +82-2-22908252
Fax: +82-2-22967502
Received: January 17, 2009 Revised: February 7, 2009 Accepted: February 14, 2009 Published online: May 14, 2009
Abstract
AIM: To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon cancer.
METHODS: Immunohistochemistry for CD133, CD24 and CD44 was performed on the tissue microarray of 523 colorectal adenocarcinomas. Medical records were reviewed and clinicopathological analysis was performed.
RESULTS: In colorectal adenocarcinoma, 128 of 523 cases (24.5%) were positive and 395 cases (75.5%) were negative for CD133 expression. Two hundred and sixty-four of 523 cases (50.5%) were positive and 259 cases (49.5%) were negative for CD24 expression. Five hundred and two of 523 cases (96%) were negative and 21 cases (4%) were positive for CD44 expression. Upon clinicopathological analysis, CD133 expression was present more in male patients (P = 0.002) and in advanced T stage cancer (P = 0.024). Correlation between CD24 expression and clinicopathological factors was seen in the degree of differentiation (P = 0.006). Correlation between CD44 expression and clinicopathological factors was seen in the tumor size (P = 0.001). Survival was not significantly related to CD133, CD24 and CD44 expression.
CONCLUSION: CD markers were related to invasiveness and differentiation of colorectal adenocarcinoma. However, CD expression was not closely related to survival.
