Raja A, Jeyaraman N, Sukumaran AM, Sridhar AS, Ramasubramanian S, Nallakumarasamy A, Muthu S, Jeyaraman M. Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to clinical applications. World J Stem Cells 2026; 18(5): 117689 [DOI: 10.4252/wjsc.v18.i5.117689]
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Author‘s Comments
The article “Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to clinical applications” was published fast and early in the World Journal of Stem Cells, underscoring its translational importance. By focusing on exosome-mediated signaling, the paper highlights how cell-free biologics derived from bone marrow MSCs can modulate inflammation, cartilage repair, and joint homeostasis. Its expedited publication reflects the urgency of advancing mechanistic insights into clinical applicability, offering a bridge between laboratory evidence and therapeutic innovation. This timely release ensures clinicians and researchers gain immediate access to evolving strategies that may redefine regenerative care in osteoarthritis.