Troponin I biomarker as a strong prognostic factor for predicting COVID-19 mortality: A systematic review

Table 1 The baseline details of studies included in our meta-analysis considering the groups with raised and normal values of troponin I

Ref.	Country	Population	Mean age	Male/female	Cutoff for TnI raising
Arcari et al[17]	Italy	Normal TnI: 39	66 ± 17	28/11	14 pg/mL
		Raised TnI: 64	79 ± 13	19/45
Fan et al[18]	China	Normal TnI: 67	58 ± 15	38/29	0.01 μg/L
		Raised TnI: 22	71 ± 12	11/11
Guo et al[19]	China	Normal TnI: 135	53 ± 13	57/78	99th percentile
		Raised TnI: 52	71 ± 9	34/18
Lala et al[20]	United States	Normal TnI: 2206	66 ± 13	1312/894318/212	0.09 ng/mL
		Raised TnI: 530	68 ± 15
Lombardi et al[21]	Italy	Normal TnI: 336	64 ± 13	234/102201/77	99th percentile
		Raised TnI: 278	71 ± 12
Lorente-Ros et al[22]	Spain	Normal TnI: 560	63 ± 12	367/193	14 ng/L
		Raised TnI: 147	78 ± 14	77/70
Raad et al[23]	United States	Normal TnI: 630	59 ± 11	280/350	18 ng/L
		Raised TnI: 390	70 ± 13	229/161
Karbalai Saleh et al[24]	Iran	Normal TnI: 271	57 ± 15	167/104	99th percentile
		Raised TnI: 115	65 ± 15	69/46
Shah et al[25]	United States	Raised TnI: 116	59 ± 14	70/123	0.05 ng/ml
		Normal TnI: 193	68 ± 14	62/54
Singh et al[26]	United States	Normal TnI: 129	53 ± 11	54/75	17 ng/L
		Raised TnI: 132	71 ± 12	70/62

Table 2 The outcome of coronavirus disease 2019 considering the groups with raised and normal values of troponin

Ref.	Raised TnI rate	Death rate	ARDS	Kidney injury	ICU admission
Arcari et al[17]	39/103	Raised TnI: 12	---	---	---
		Normal TnI: 7
Fan et al[18]	22/89	---	Raised TnI: 20	Raised TnI: 9	---
			Normal TnI: 12	Normal TnI: 10
Guo et al[19]	52/187	Raised TnI:3 1	Raised TnI: 30	Raised TnI: 14	Raised TnI: 31
		Normal TnI: 12	Normal TnI: 16	Normal TnI: 4	Normal TnI: 14
Lala et al[20]	530/2736	Raised TnI: 223	---	---	---
		Normal TnI: 102
Lombardi et al[21]	278/614	Raised TnI: 102	---	Raised TnI: 41	---
		Normal TnI: 43		Normal TnI: 13
Lorente-Ros et al[22]	147/707	Raised TnI: 60; Normal TnI: 130	---	---	Raised TnI: 7Normal TnI: 5
Raad et al[23]	390/1020	Raised TnI: 128	Raised TnI: 93	Raised TnI: 224	Raised TnI: 105
		Normal TnI: 52	Normal TnI: 64	Normal TnI:178	Normal TnI:93
Karbalai Saleh et al[24]	115/386	Raised TnI: 47	Raised TnI: 46	Raised TnI: 35	Raised TnI: 41
		Normal TnI: 30	Normal TnI: 30	Normal TnI: 25	Normal TnI: 38
Shah et al[25]	116/309	Raised TnI: 44	---	Raised TnI: 13	Raised TnI: 58
		Normal TnI: 22		Normal TnI: 5	Normal TnI: 52
Singh et al[26]	132/276	Raised TnI: 20	Raised TnI: 29	---	Raised TnI: 63
		Normal TnI: 5	Normal TnI: 10		Normal TnI: 25

Table 3 The baseline details of studies included in our meta-analysis considering the survived and non-survived groups

Ref.	Country	Population	Mean age	Male/female	Mean TnI
Aladağ and Atabey[27]	Turkey	Survived: 35	68 ± 14	22/13	Survived: 0.001 ng/mL
		Non-survived: 15	68 ± 15	6/9	Non-survived: 0.010 ng/mL
Deng et al[28]	China	Survived: 212	62 ± 11	97/115	Survived: 0.006 ng/mL
		Non-survived: 52	74 ± 15	33/19	Non-survived: 0.051 ng/mL
Liberati et al[15]	Italy	Survived: 425	61 ± 13	287/138	Survived: 0.006 ng/mL
		Non-survived: 98	76 ± 10	68/30	Non-survived: 0.036 ng/mL
Nie et al[29]	China	Survived: 200	60 ± 11	180/20	Survived: 0.002 ng/mL
		Non-survived: 111	72 ± 12	88/23	Non-survived: 0.032 ng/mL
Rath et al[30]	Germany	Survived: 107	67 ± 15	65/42	Survived: 0.014 ng/mL
		Non-survived: 16	73 ± 16	12/4	Non-survived: 0.024 ng/mL
Shi et al[31]	China	Survived: 609	61 ± 13	287/322	Survived: 0.006 ng/mL
		Non-survived: 62	74 ± 15	35/27	Non-survived: 0.023 ng/mL
Yang et al[32]	China	Survived: 145	57 ± 13	77/68	Survived: 0.004 ng/mL
		Non-survived: 58	67 ± 15	38/20	Non-survived: 0.020 ng/mL