Meta-Analysis
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Aug 28, 2021; 9(4): 377-388
Published online Aug 28, 2021. doi: 10.13105/wjma.v9.i4.377
Systematic review and Meta-analysis of efficacy and safety of dienogest in treatment of endometriosis
Shao-Chong Lin, Xin-Yue Wang, Xi-Ling Fu, Wen-Hui Yang, Han Wu, Yang Bai, Zhong-Na Shi, Jun-Peng Du, Bao-Jin Wang
Shao-Chong Lin, Xin-Yue Wang, Xi-Ling Fu, Yang Bai, Zhong-Na Shi, Bao-Jin Wang, Department of Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Wen-Hui Yang, Pharmacy Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Han Wu, Medical School of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Jun-Peng Du, Department of Pediatric Surgery, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Lin SC, Wang BJ, and Du JP conceived and designed the study; Wang XY and Fu XL researched, extracted, and evaluated the data; Yang WH, Wu H, and Bai Y performed data analyses; Lin SC and Shi ZN wrote the manuscript; all authors read and approved the final manuscript.
Supported by the Science and Technology Department of Henan Province, No. 132300410352.
Conflict-of-interest statement: The authors deny any conflict of interest for this manuscript.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bao-Jin Wang, PhD, Doctor, Department of Gynecology, The Third Affiliated Hospital of Zhengzhou University, No. 7 Kangfu Front Street, Erqi District, Zhengzhou 450052, Henan Province, China. 2995269936@qq.com
Received: June 16, 2021
Peer-review started: June 16, 2021
First decision: July 6, 2021
Revised: July 17, 2021
Accepted: August 20, 2021
Article in press: August 20, 2021
Published online: August 28, 2021
Processing time: 79 Days and 1.6 Hours
Core Tip

Core Tip: We comprehensively and systematically analyzed the safety and effectiveness of dienogest for the treatment of endometriosis-related pain. Only high-quality randomized controlled trials that compared dienogest with other drugs, such as gonadotrophin-releasing hormone analogues and placebo, were included in the meta-analysis. The results provide guidelines for the standardization of the clinical use of medications for endometriosis and would improve the choice of medications for patients.