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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Sep 18, 2025; 13(3): 111716
Published online Sep 18, 2025. doi: 10.13105/wjma.v13.i3.111716
Published online Sep 18, 2025. doi: 10.13105/wjma.v13.i3.111716
Comparison of outcomes following valve-sparing aortic root replacement in patients with bicuspid and tricuspid aortic valves: A meta-analysis
Lidya Fekadu Adugna, Department of Cardiology, ELOuzeir Cardiac Center, Addis Ababa 1000, Ethiopia
Natnael Fitsum Asfeha, Elsabeth Alemayehu Haile, Simon Zemenfes Hailu, Mussie Tsegaye Anjulo, Department of Medicine, Mekelle University, College of Health Sciences, Tigray Region 231, Ethiopia
Mohammed Ebrahim Musa, Department of Medicine, St. Paul’s Hospital Millennium Medical College, Addis Ababa 1000, Ethiopia
Heran Teferi Tafesse, Department of Medicine, Dalian Medical University, Dalian 116044, Liaoning Province, China
Zainab Haider Khan, Department of Cardiology, Avalon University School of Medicine, Willemstad 4797, Netherlands
Asraf Hussain, Department of Cardiology, Chitwan Medical College, Bharatpur 33915, Nepal
Co-first authors: Lidya Fekadu Adugna and Natnael Fitsum Asfeha.
Author contributions: Adugna LF supervised the study; Adugna LF and Asfeha NF conceptualized the study and performed formal analysis; Adugna LF, Asfeha NF, and Hussain A wrote the original draft; Asfeha NF and Anjulo MT administered the project; Musa ME, Haile EA, and Tafesse HT designed the methodology; Musa ME, Haile EA, and Khan ZH reviewed and edited the manuscript; Musa ME and Hussain A curated data; Haile EA, Hailu SZ, and Anjulo MT conducted the investigation; Hailu SZ and Anjulo MT handled software; Hailu SZ and Tafesse HT managed visualization; Tafesse HT and Khan ZH provided resources; Khan ZH and Hussain A validated the study; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Asraf Hussain, MD, Department of Cardiology, Chitwan Medical College, Bharatpur-10, Chitwan, Bharatpur 33915, Nepal. drasrafcardiology@gmail.com
Received: July 8, 2025
Revised: July 16, 2025
Accepted: August 29, 2025
Published online: September 18, 2025
Processing time: 64 Days and 23.4 Hours
Revised: July 16, 2025
Accepted: August 29, 2025
Published online: September 18, 2025
Processing time: 64 Days and 23.4 Hours
Core Tip
Core Tip: Valve-sparing aortic root replacement (VSARR) preserves native valves in patients with bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV), reducing prosthetic valve complications. Our meta-analysis reveals comparable short-term safety between BAV and TAV patients but a significantly higher long-term reintervention risk in BAV patients. These findings highlight the need for tailored surgical strategies and vigilant long-term monitoring to optimize outcomes in BAV patients undergoing VSARR.