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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Sep 18, 2025; 13(3): 107588
Published online Sep 18, 2025. doi: 10.13105/wjma.v13.i3.107588
Published online Sep 18, 2025. doi: 10.13105/wjma.v13.i3.107588
Ambient effects on neural stem cells: Insights from Drosophila
Xu-Ming Ren, Qian Zhang, Hao Zhang, Li-Juan Zhang, Yue Yu, Huan-Ping An, Key Laboratory for Neural Precursor Cell Temporal Regulation and Diseases of Shaanxi Universities, Hanzhong Vocational and Technical College, Hanzhong 723002, Shaanxi Province, China
Hao Zhang, Center for Disease Control and Prevention in Hanzhong, Center for Disease Control and Prevention in Hanzhong, Hanzhong 723000, Shaanxi Province, China
Hao Zhang, Clinical School of Cardiovascular Disease, Tianjin Medical University, Tianjin 300450, China
Qing-Juan Chen, Department of Oncology, 3201 Hospital, Hanzhong 723000, Shaanxi Province, China
Co-first authors: Xu-Ming Ren and Qian Zhang.
Co-corresponding authors: Qing-Juan Chen and Huan-Ping An.
Author contributions: An HP, Chen QJ, Ren XM, and Zhang Q contributed to the study conceptualization and design; Ren XM, Zhang Q, and Zhang H were responsible for the information collection and manuscript drafting and revisions; Zhang L and Yu Y provided technical and expert support for the information categorization and key factors’ summarization; Ren XM proposed, designed, and conducted the analyses of the microenvironment and systemic environment references, and prepared the first draft of the manuscript; Zhang Q was responsible for the external environment and spatial factor information collection, and prepared the original figures; An HP applied for and obtained funding for this research project; An HP and Chen QJ supervised the logistical process of this project and played important and indispensable roles in the study design, information conceptualization, and manuscript preparation as the co-corresponding authors; An HP and Chen QJ made crucial and indispensable contributions towards the completion of the project and its manuscript, and are therefore listed as the co-first authors; All authors have read and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 32000506; and the Key Laboratory of Shaanxi Universities, No. 0240037.
Conflict-of-interest statement: The authors have no conflicts of interests to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huan-Ping An, PhD, Professor, Key Laboratory for Neural Precursor Cell Temporal Regulation and Diseases of Shaanxi Universities, Hanzhong Vocational and Technical College, No. 81 the Westside of 316 National Road, Hantai District, Hanzhong 723002, Shaanxi Province, China. anhuanping_001@126.com
Received: March 27, 2025
Revised: May 13, 2025
Accepted: September 1, 2025
Published online: September 18, 2025
Processing time: 167 Days and 20.8 Hours
Revised: May 13, 2025
Accepted: September 1, 2025
Published online: September 18, 2025
Processing time: 167 Days and 20.8 Hours
Core Tip
Core Tip: Neural stem cells (NSCs) are fundamental to the formation of neuronal circuitry, and their dysfunction can lead to systemic neural impairments. While intrinsic regulatory mechanisms of NSCs have been studied extensively, emerging evidence highlights the critical contributions of extrinsic factors, such as glial interactions, intertissue signaling, oxygen tension, and irradiation, to NSC development. This mini-review synthesizes current insights into these extrinsic regulators, leveraging the Drosophila model to elucidate their role in NSC dynamics and neural system integrity.