Clinical characteristics and ABCC2 genotype in Dubin-Johnson syndrome: A case report and review of the literature

Table 1 The clinicopathological parameters of a Dubin-Johnson syndrome patient

Method	Index	Result
Liver function	TBIL	69.3 μmol/L
	DBIL	40.8 μmol/L
	IBIL	28.5 μmol/L
Routine urinalysis	Urinary bilirubin	+
	HbsAb	+
	HBeAb	+
	HBcAb	+
Routine blood analysis	HBV-DNA	-
	Non-chronic hepatitis virus markers	-
	ANA antibody spectrum	-
	Anti-neutrophil cytoplasmic antibody	-
	Autoimmune liver disease antibody spectrum	-
	Markers of ceruloplasmin and iron metabolism	-
Immunohistochemistry	HbsAg	-
	HbcAg	-
	Hepatocytes	+
	CD10 (bile capillaries)	+
	CD3 (hepatic lobules)	+
	CD3 (inflammatory cells in the hepatic duct)	+
	CD34 (blood vessels)	+
	CD68 (Kupffer cells in the hepatic sinus)	+
	CD68 (macrophages in the portal area)	-
	MUMI (inflammatory cells in the portal area)
	CK7/CK19 (interlobular bile ducts)

TBIL: Total bilirubin; DBIL: Direct bilirubin; IBIL: Indirect bilirubin; HBV: Hepatitis B virus; ANA: Antinuclear antibody.