Retrospective Study
Copyright ©The Author(s) 2021.
World J Clin Cases. Nov 26, 2021; 9(33): 10088-10097
Published online Nov 26, 2021. doi: 10.12998/wjcc.v9.i33.10088
Table 1 Clinicopathological characteristics of the study patients (n =1152)
Age, yr66.4 ± 11.6
Sex (male/female)729 (63.3)/423 (36.7)
Location (left-sided/right-sided)788 (68.4)/364 (31.6)
Tumor size (mm)21.2 ± 13.3
Polypoid/non-polypoid growth (polypoid/non-polypoid)714 (62.0)/438 (38.0)
Adenomatous component (±)466 (40.5)/686 (59.5)
Morphology (flat/ protruded/ depressed)397 (34.5)/475 (41.2)/280 (24.3)
Initial treatment (endoscopic/surgical)710 (61.6)/442 (38.4)
Surgical resection1798 (69.3)/354 (30.7)
Depth of invasion (T1b/T1a)826 (71.7)/326 (28.3)
Histological grade (Por or Muc2/tub1 or tub2)58 (5.0)/1094(95.0)
Vascular invasion (±)322 (28.0)/830 (72.0)
Lymphatic invasion (±)342 (29.7)/810 (70.3)
Tumor budding (BD 2 or 3/BD 1)242 (21.0)/910 (79.0)
1Surgical resection: Initial and additional surgical resection.
2Por or Muc, poorly differentiated adenocarcinoma or mucinous carcinoma. Results are expressed as mean ± SD or number of patients (%), as appropriate.
Table 2 Comparison of clinicopathological characteristics between < 10 mm and ≥ 10 mm tumors in total cohort T1 colorectal cancers (n = 1152)
< 10 mm (n = 116)
≥ 10 mm (n = 1036)
P value
Age, yr66.8 ± 11.566.4 ± 11.60.72
Sex (male/female)84 (72.4)/32 (27.6)645 (62.3)/391 (37.7)0.03
Location (left-sided/right-sided)77 (66.4)/39 (33.6)710 (68.5)/326 (31.5)0.67
Tumor size (mm)7.5 ± 1.222.5 ± 12.60.08
Polypoid/non-polypoid growth (polypoid/non-polypoid)50 (43.1)/66 (56.9)664 (64.1)/372 (35.9)< 0.01
Adenomatous component (±)34 (29.3)/82 (70.7)432 (41.7)/604 (58.3)< 0.01
Morphology(flat/ protruded/ depressed)10 (8.6)/46 (39.7)/60 (51.7)387 (37.4)/429 (41.4)/220 (21.2)< 0.01
Initial treatment (endoscopic/surgical)86 (74.1)/30 (25.9)624 (60.2)/412 (39.8)< 0.01
Surgical resection173 (62.9)/43 (37.1)725 (70.0)/311 (30.0)0.14
Depth of invasion (T1b/T1a)72 (62.1)/44 (37.9)754 (72.8)/282 (27.2)0.02
Histological grade (Por or Muc2/tub1 or tub2)3 (2.6)/113 (97.4)55 (5.3)/981 (94.7)0.26
Vascular invasion (±)35 (30.2)/81 (69.8)287 (27.7)/749 (72.3)0.59
Lymphatic invasion (±)38 (32.8)/78 (67.2)304 (29.3)/732 (70.7)0.45
Tumor budding (BD 2 or 3/BD 1)24 (20.7)/92 (79.3)218 (21.0)/818 (79.0)1.00
1Surgical resection: initial and additional surgical resection.
2Por or Muc, poorly differentiated adenocarcinoma or mucinous carcinoma. Results are expressed as mean ± SD or number of patients (%), as appropriate.
Table 3 Comparison of clinicopathological characteristics between < 10 mm and ≥ 10 mm tumors in surgical resection cohort T1 colorectal cancers (n = 798)
< 10 mm (n = 73)
≥ 10 mm (n = 725)
P value
Age, yr66.0 ± 11.865.5 ± 11.20.71
Sex (male/female)55 (75.3)/18 (24.7)438 (60.4)/287 (39.6)0.01
Location (left-sided/right-sided)51 (69.9)/22 (30.1)516 (71.2)/209 (28.8)1.00
Tumor size (mm)7.6 ± 1.122.3 ± 12.0< 0.01
Polypoid/non-polypoid growth (polypoid/non-polypoid)26 (35.6)/47 (64.4)473 (65.2)/252 (34.8)< 0.01
Adenoma component (±)15 (20.5)/58 (79.5)236 (32.6)/489 (67.4)0.04
Morphology (flat/ protruded/ depressed)4 (5.5)/ 24 (32.9)/ 45 (61.6)307 (42.3)/214 (29.5)/204 (28.1)0.03
Initial treatment (endoscopic/surgical)43 (58.9)/30 (41.1)316 (43.6)/409 (56.4)0.01
Depth of invasion (T1b/T1a)67 (91.8)/6 (8.2)631 (87.0)/94 (13.0)0.35
Histological grade (Por or Muc1/tub1 or tub2)3 (4.1)/70 (95.9)47 (6.5)/678 (93.5)0.61
Vascular invasion (±)32 (43.8)/41 (56.2)261 (36.0)/464 (64.0)0.20
Lymphatic invasion (±)34 (46.6)/39 (53.4)270 (37.2)/455 (62.8)0.13
Tumor budding (BD 2 or 3/BD 1)21 (28.8)/52 (71.2)193 (26.6)/532 (73.4)0.68
Lymph node metastasis (±)9 (12.3)/64 (87.7)79 (10.9)/ 646 (89.1)0.70
1Por or Muc, poorly differentiated adenocarcinoma or mucinous carcinoma. Results are expressed as mean ± SD or number of patients (%), as appropriate.