Rare mutation in MKRN3 in two twin sisters with central precocious puberty: Two case reports

Table 1 Summary of the clinical data of the two patients

	Patient A	Patient B
Age at onset (yr)	6.25	6.33
Age at referral (yr)	6.66	6.5
Weight (kg)	23	26.7
Height (cm)	119.6	122.6
Bone age (yr)	9	9
Tanner stage	B2	B2
Pubarche stage	PH1	PH1
Basal LH (mIU/mL)	0.13	N/A
Peak LH (mIU/mL)	4.71	15.81
Basal FSH (mIU/mL)	2.71	N/A
Peak FSH (mIU/mL)	16.48	N/A
Estradiol (pg/ml)	25.26	N/A
Peak LH/FSH	0.29	N/A
Uterine (mL)	2.9	5.3
Left Ovary (mL)	1.2	1.9
Right Ovary (mL)	1.7	1.8
Brain magnetic resonance imaging	Normal	Normal