Acute pancreatitis with hypercalcemia caused by primary hyperparathyroidism associated with paraneoplastic syndrome: A case report and review of literature

Table 1 Selected initial laboratory values

WBC (4-10) (× 109/L)	26.5
Neutrophil percentage (50-70) (%)	95
PLT (100-300) (× 109/L)	214
Hb (113-151) (g/L)	156
Albumin (35-53) (g/L)	26.8
ALT (4-40) (U/L)	19.5
AST (4-40) (U/L)	26.6
CRP (0-10) (mg/L)	109
PCT (0-0.5) (ng/mL)	4.35
Serum amylase (0-200) (U/L)	1222.5
Urine amylase (0-1000) (U/L)	1433.0
Creatinine (44-97) (μmol/L)	172.3
Serum calcium (2.13-2.65) (mmol/L)	4.72
PTH (15-65) (pg/mL)	366.90
CA-125 (0-35) (U/mL)	142.5
LDH (80-250) (U/L)	457.3
Ferritin (11-306) (ng/mL)	747
25-OH-VD (20-100) (ng/mL)	< 3

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CA-125: Carbohydrate antigen 125; CRP: C-reactive protein; Hb: Hemoglobin; LDH: Lactate dehydrogenase; PCT: Procalcitonin; PTH: Parathyroid hormone; PLT: Platelet; WBC: White blood cell; 25-OH-VD: 25-hydroxyvitamin D.

Table 2 Overview of previously described cases of paraneoplastic syndrome and pancreatitis

Ref.	Cancer	Along with increased PTH
Danne et al[12], 1985	Gastrinoma	No
Yamamoto et al[13], 2003	Zollinger-Ellison syndrome	No
Baffy et al[14], 2000	Zollinger-Ellison syndrome	No
Belhassen-García et al[15], 2009	Lung cancer	No
Saliba et al[16], 2006	Lung carcinoma	No
Akinosoglou et al[17], 2014	Lung cancer	No
Casadei Gardini et al[18], 2016	Lung cancer	No
Leone et al[19], 1998	Pancreatic adenocarcinoma	No
Tanvetyanon et al[20], 2005	Myelodysplastic syndrome	No
Lekakis et al[21], 2012	Breast cancer	No
Miyazaki et al[22], 2019	Intraductal papillary neoplasm of bile duct	No
Mittra and Davidzon[23], 2014	Hodgkin lymphoma	No
Colaut et al[24], 2002	Thymoma	No
Tomiyama et al[25], 2008	Thymoma	No
Wynn et al[26], 2004	Ovarian carcinoma	No
Seifert and Seemann[27], 1967	Ovarian carcinoma	No

PTH: Parathyroid hormone.