Effective immune-inflammation index for ulcerative colitis and activity assessments

Table 1 Clinical and laboratory characteristics of patients with ulcerative colitis and healthy controls

	Control, n = 172	Ulcerative colitis, n = 172	P value
Male, n (%)	96 (55.81%)	91 (52.90%)	0.588
Age (yr)	47.50 (37.00-56.00)	48.00 (35.00-57.00)	0.545
WBC (× 109/L)	5.37 (4.47-6.29)	7.26 (5.85-9.23)	< 0.001
HB (g/L)	138.00 (125.00-152.50)	131.00 (122.00-143.00)	0.001
PLT (× 109/L)	213.00 (179.50-251.00)	245.00 (197.00-312.00)	< 0.001
N (× 109/L)	3.11 (2.55-3.86)	5.48 (4.07-7.25)	< 0.001
L (× 109/L)	1.67 (1.35-2.08)	1.25 (0.97-1.70)	< 0.001
M (× 109/L)	0.30 (0.24-0.37)	0.33 (0.18-0.49)	0.295
SII (× 109/L)	384.86 (282.31-557.42)	1063.23 (587.24-1787.87)	< 0.001
NLR, %	1.83 (1.45-2.47)	4.31 (2.73-6.47)	< 0.001
PLR, %	127.49 (98.71-156.21)	191.87 (130.97-263.89)	< 0.001

HB: Hemoglobin; L: Lymphocytes; M: Monocytes; N: Neutrophils; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; PLT: Platelet; SII: Systemic immune-inflammation index; WBC: White blood cell.

Table 2 Correlation analysis between systemic immune-inflammation index and endoscopic score

	MES		Extent		DUBLIN		UCEIS
	r	P value	r	P value	r	P value	r	P value
SII	0.124	0.106	0.174	0.023	0.193	0.011	0.227	0.003
NLR	0.068	0.375	0.146	0.056	0.139	0.068	0.130	0.088
PLR	0.043	0.577	0.060	0.432	0.074	0.336	0.108	0.158

DUBLIN: Degree of Ulcerative Colitis Burden of Luminal Inflammation; MES: Mayo endoscopic score; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; SII: Systemic immune-inflammation index; UCEIS: Ulcerative Colitis Endoscopic Index of Severity.

Table 3 Receiver operating characteristic analyses of systemic immune-inflammation index, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in diagnosing ulcerative colitis

Variable	Cut-off	AUC (95%CI)	Sensitivity, %	Specificity, %	P value
SII	> 562.22	0.856 (0.814-0.891)	79.65	76.16	< 0.001
NLR	> 2.66	0.858 (0.817-0.893)	75.00	82.56	< 0.001
PLR	> 156.54	0.754 (0.705-0.799)	65.70	76.16	< 0.001

AUC: Area under the receiver operating characteristic curve; CI: Confidence interval; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; SII: Systemic immune-inflammation index.

Table 4 Multivariate logistic regression analyses of the relationship between inflammatory indicators and ulcerative colitis

	B	P value	Odds ratio	95%CI
SII
346.44	Reference
346.45-574.88	0.56	0.241	1.76	0.69-4.52
574.89-1084.51	1.24	0.031	3.45	1.12-10.63
1084.52	3.03	0.001	20.64	3.57-119.18
NLR
1.69	Reference
1.70-2.53	0.64	0.163	1.91	0.77-4.71
2.54-4.60	1.32	0.010	3.73	1.37-10.18
4.61	2.53	0.001	12.52	2.77-56.60
PLR
111.93	Reference
111.94-149.11	-0.15	0.718	0.87	0.40-1.90
149.11-203.33	-0.26	0.560	0.77	0.32-1.84
203.34	-0.38	0.517	0.68	0.21-2.18

NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; SII: Systemic immune-inflammation index.

Table 5 Multivariate logistic regression analyses of the relationship between inflammatory indicators and degree of ulcerative colitis burden of luminal inflammation 3

	B	P value	Odds ratio	95%CI
SII
589.63	Reference
589.64-1047.18	0.51	0.372	1.66	0.55-5.04
1047.19-1776.79	0.86	0.299	2.36	0.47-11.98
1776.80	2.45	0.027	11.53	1.33-100.15
NLR
2.66	Reference
2.67-4.23	1.09	0.047	2.96	1.01-8.65
4.24-6.46	0.85	0.237	2.33	0.57-9.49
6.47	-0.20	0.820	0.82	0.15-4.49
PLR
132.35	Reference
132.36-190.31	-0.59	0.286	0.56	0.19-1.63
190.32-263.47	-0.33	0.620	0.72	0.20-2.65
263.48	-1.06	0.201	0.35	0.07-1.76

NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; SII: Systemic immune-inflammation index.

Table 6 Multivariate logistic regression analyses of the relationship between inflammatory indicators and ulcerative colitis endoscopic index of severity 5

	B	P value	Odds ratio	95%CI
SII
589.63	Reference
589.64-1047.18	1.09	0.146	2.98	0.69-12.94
1047.19-1776.79	1.57	0.129	4.81	0.63-36.56
1776.80	2.92	0.012	18.46	1.89-180.30
NLR
2.66	Reference
2.67-4.23	0.06	0.934	1.06	0.27-4.23
4.24-6.46	0.05	0.954	1.05	0.20-5.41
6.47	-0.61	0.534	0.54	0.08-3.71
PLR
132.35	Reference
132.36-190.31	-1.06	0.139	0.35	0.09-1.41
190.32-263.47	-0.96	0.212	0.38	0.09-1.73
263.48	-1.20	0.174	0.30	0.05-1.70

NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio; SII: Systemic immune-inflammation index.