Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 is a diagnostic and prognostic biomarker for hepatocellular carcinoma

Table 1 The association between phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 and clinical features in 90 hepatocellular carcinoma patients

Characteristics	P-Rex1 expression1		P value	χ2
	High	Low
Age (yr)
≤ 50	13	11	0.634	0.227
> 50	32	34
Gender
Male	33	36	0.455	0.559
Female	12	9
HBV infection
Yes	33	5	< 0.001	35.709
No	12	40
Lymph node invasion
Yes	37	11	< 0.001	30.179
No	8	34
Distant metastasis
Yes	22	2	< 0.001	22.727
No	23	43
AFP level (ng/mL)
< 20	8	8	< 0.001	14.708
20 ≤ AFP ≤ 200	6	22
> 200	31	15
Total	45	45

¹The median expression of 90 cases of tumor tissues was set as the cut-off. HBV: Hepatitis B virus; AFP: Alpha-fetoprotein; P-Rex1: Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1.

Table 2 The association of phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 expression with median survival time in the 5-yr survival analysis

Survival type	P-Rex1 expression1		P value	HR
	High	Low
OS
Total	25.5	14	0.026	0.67 (0.47-0.96)
AJCC-T1	45.7	17.8	0.0421	0.54 (0.29-0.99)
Stage 1	54.1	14.6	0.038	0.52 (0.28-0.98)
PFS
Total	40.97	18.7	0.01	0.63 (0.44-0.90)
AJCC-T1	58.17	34.4	0.034	0.54 (0.30-0.96)
Stage 1	58.17	34.4	0.046	0.56 (0.31-1.00)
RFS
Total	37.23	16.83	0.0059	0.62 (0.44-0.88)
AJCC-T1	56.67	16.83	0.0073	0.46 (0.26-0.82)
Stage 1	25.87	13.03	0.012	0.50 (0.29-0.87)

¹The hepatocellular carcinoma patients were divided into high or low phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 expression groups according to the median expression level. OS: Overall survival; HR: Hazard ratio; AJCC-T1: T1 stage based on the American Joint Committee on Cancer; P-Rex1: Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1; PFS: Progression-free survival; RFS: Relapse-free survival.