Multi-organ IgG4-related disease continues to mislead clinicians: A case report and literature review

Table 1 Immunological tests

Immunological tests	Value	Normal range
β-2 Glycoprotein-1 antibodies Ig G, A, M (o.d.)	0.512 (positive)	0.497
Cardiolipin antibodies Ig G, A, M (o.d.)	0.588 (positive)	0.552
Antinuclear antibodies	> 1:200 (positive) Dense fine speckled	< 1:40
Anti-neutrophil cytoplasmic antibodies	< 1:10 (negative)	< 1:10
Rheumatoid factor	< 20.0	< 30 U/mL
Complement C4	0.15	0.15–0.57 g/L
Complement C3c	1.09	0.9–1.8 g/L
ENA: nRNP/Sm	Negative	Negative
ENA: Sm	Negative	Negative
ENA: SS-A	Negative	Negative
ENA: SS-B	Negative	Negative
ENA: Ro-52	Negative	Negative
ENA: Scl-70	Negative	Negative
ENA: PM-Scl	Negative	Negative
ENA: Jo-1	Negative	Negative
ENA: CENP-B	Negative	Negative
ENA: PCNA	Negative	Negative
ENA: dsDNA	Negative	Negative
ENA: Nucleosome	Negative	Negative
ENA: Histones	Negative	Negative
ENA: Ribosomal P-protein	Negative	Negative
ENA: AMA-M2	Negative	Negative

o.d.: Optical density; ENA: Extractable nuclear antigens; SS: Sjögren's syndrome.

Table 2 Main laboratory findings

Main laboratory findings	Value	Normal range
White blood count	3.62	4.0-9.8 × 109/L
Haemoglobin	144	128-160 g/L
Platelet count	160	130-400 × 109/L
C reactive protein	0.42	≤ 5 mg/L
Glucose	6.2	4.2-6.1 mmol/L
Aspartate aminotransferase	28	< 40 U/L
Alanine aminotransferase	34	< 40 U/L
γ-glutamyl transferase	30	≤ 36 U/L
Alkaline phosphatase	68	40-150 U/L
Lactate dehydrogenase	225	125-243 U/L
Lipase	4	< 8-78 U/L
Thyrotropin	1.402	0.4-4.0 mU/L
Total bilirubin	12.5	< 21 μmol
Total protein	55.6	66-83 g/L
K+	4.3	3.8-5.3 mmol/L
Na+	140	134-145 mmol/L
Fe	17.4	9.5-29.9 µmol/L
Ferritin	170.4	20-300 mcg/L
Prostate-specific antigen	0.303	< 4.0 ng/mL
Prothrombin time	62	70%-130%
INR by Owren	1.24	0.90-1.19
Creatinine	51	62-11 µmol/L
Urea	4.2	2.5-7.5 mmol/L