Recurrent acute liver failure associated with novel SCYL1 mutation: A case report

Table 1 Clinical phenotype in three fever-associated acute liver failure episodes

	Age 3 y 6 mo	Age 6 y 3 mo	Age 8 y 5mo	Range
Febrile illness before ALF	Yes	Yes	Yes
Using antipyretics before ALF	Yes	No	Yes
Duration	> 4 mo	> 1 mo	> 1 mo
Max TB (μmol/L)	504.0	305.7	554.0	5.1-17.1
Max DB (μmol/L)	288.0	125.0	264.7	0-6.0
Max ALT (IU/L)	414	1865	881	0-40
Max AST (IU/L)	2050	4900	1648	15-60
Max GGT (IU/L)	117	39	70	7-50
Max PT (s)	24.9	29.5	26.7	11.0-14.5
Hepatomegaly	Yes	Yes	Yes
Splenomegaly	No	No	Yes
Additional features	Antipyretic- induced hepatopathy diagnosed	Multi-organ involvement1	Multi-organ involvement2

Multi-organ involvement¹: Acute liver failure, severe acute pancreatitis, bilateral pneumonia, alimentary tract hemorrhage, and septic shock; Multi-organ involvement²: Acute liver failure, bronchopneumonia, moderate anemia, ventricular premature beats, hypokalemia, hyponatremia, and bilateral femoral abnormalities. ALF: Acute liver failure; TB: Total bilirubin; DB: Direct bilirubin; ALT: Alanine transaminase; AST: Aspartate transaminase; GGT: gamma-glutamyl transpeptidase; PT: Prothrombin time; Max: Maximum.