Hydroxychloroquine-induced renal phospholipidosis resembling Fabry disease in undifferentiated connective tissue disease: A case report

doi:10.12998/wjcc.v7.i24.4377

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Dec 26, 2019 (publication date) through Oct 22, 2025

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Case Report

World J Clin Cases. Dec 26, 2019; 7(24): 4377-4383
Published online Dec 26, 2019. doi: 10.12998/wjcc.v7.i24.4377

Table 1 The timeline of treatment

Time	Symptoms	Diagnoses	Treatments
2008	Canker sores	Undifferentiated connective tissue disease	Low doses of prednisone: 5 mg
	White blood cell count: 1.8 × 10⁹/L
	ANA: 1:320(+)
	Blood complements: Normal
	Serum creatinine: 66 µmol/L
2016	Facial erythema	Undifferentiated connective tissue disease	Hydroxychloroquine; Prednisone
2016	Decreased blood complements	Undifferentiated connective tissue disease	Hydroxychloroquine; Prednisone
April 2018	Weight loss	Undifferentiated connective tissue disease; Hydroxychloroquine -induced renal phospholipidosis	Withdrawal of hydroxychloroquine; Prednisone
	Weakness
	White blood count: 2.7-4.7 × 10⁹/L
	Urine erythrocytes: 28/µL
	Serum creatinine: 58 µmol/L
	24-h urinary protein, quantitative: 1120 mg
	ANA: 1:80(+)
	Complement C3: 0.58 g/L
	Complement C4: 0.09 g/L
	Renal biopsy: Renal phospholipidosis
	Mutation of GLA gene: Negative

ANA: Antinuclear antibody.

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Citation: Wu SZ, Liang X, Geng J, Zhang MB, Xie N, Su XY. Hydroxychloroquine-induced renal phospholipidosis resembling Fabry disease in undifferentiated connective tissue disease: A case report. World J Clin Cases 2019; 7(24): 4377-4383
URL: https://www.wjgnet.com/2307-8960/full/v7/i24/4377.htm
DOI: https://dx.doi.org/10.12998/wjcc.v7.i24.4377